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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2zb1 GK4 Mitogen-activated protein kinase 14

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2zb1 GK4Mitogen-activated protein kinase 14 / 1.124
2zb0 GK3Mitogen-activated protein kinase 14 / 0.811
3iph G11Mitogen-activated protein kinase 14 / 0.750
3e93 19BMitogen-activated protein kinase 14 / 0.739
3d7z GK5Mitogen-activated protein kinase 14 / 0.720
3bx5 304Mitogen-activated protein kinase 14 / 0.719
4i5h G17Mitogen-activated protein kinase 1 2.7.11.24 0.712
3rin I2OMitogen-activated protein kinase 14 / 0.708
2ofv 242Tyrosine-protein kinase Lck 2.7.10.2 0.702
3d83 GK6Mitogen-activated protein kinase 14 / 0.702
3dt1 P40Mitogen-activated protein kinase 14 / 0.697
3kq7 KQ7Mitogen-activated protein kinase 14 / 0.697
4kin 1M8Mitogen-activated protein kinase 14 / 0.696
4uxq 0LIFibroblast growth factor receptor 4 2.7.10.1 0.689
4aa0 AA0Mitogen-activated protein kinase 14 / 0.681
2rg5 279Mitogen-activated protein kinase 14 / 0.679
3e92 G6AMitogen-activated protein kinase 14 / 0.679
4aa5 NQBMitogen-activated protein kinase 14 / 0.678
3fkl FKLMitogen-activated protein kinase 14 / 0.676
4ckr DI1Epithelial discoidin domain-containing receptor 1 2.7.10.1 0.675
3ds6 A17Mitogen-activated protein kinase 14 / 0.669
4tyj 0LIFibroblast growth factor receptor 4 2.7.10.1 0.667
1w83 L11Mitogen-activated protein kinase 14 / 0.665
3s4q NK0Mitogen-activated protein kinase 14 / 0.657
2hyy STITyrosine-protein kinase ABL1 2.7.10.2 0.654
3mvl 38PMitogen-activated protein kinase 14 / 0.654
3gcv SS6Mitogen-activated protein kinase 14 / 0.652
4c8b 0LIReceptor-interacting serine/threonine-protein kinase 2 2.7.11.1 0.651