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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2zb0 GK3 Mitogen-activated protein kinase 14

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2zb0 GK3Mitogen-activated protein kinase 14 / 1.173
2zb1 GK4Mitogen-activated protein kinase 14 / 0.811
3e93 19BMitogen-activated protein kinase 14 / 0.802
3rin I2OMitogen-activated protein kinase 14 / 0.780
3d83 GK6Mitogen-activated protein kinase 14 / 0.765
4aa0 AA0Mitogen-activated protein kinase 14 / 0.762
3fkl FKLMitogen-activated protein kinase 14 / 0.735
4kiq 1RAMitogen-activated protein kinase 14 / 0.735
3kq7 KQ7Mitogen-activated protein kinase 14 / 0.731
4kin 1M8Mitogen-activated protein kinase 14 / 0.725
3fsk RO6Mitogen-activated protein kinase 14 / 0.720
1wbn L09Mitogen-activated protein kinase 14 / 0.714
4aa5 NQBMitogen-activated protein kinase 14 / 0.712
3e92 G6AMitogen-activated protein kinase 14 / 0.709
1w83 L11Mitogen-activated protein kinase 14 / 0.708
4eh6 0ONMitogen-activated protein kinase 14 / 0.699
3hv5 R24Mitogen-activated protein kinase 14 / 0.696
2zaz GK1Mitogen-activated protein kinase 14 / 0.692
3lfa 1N1Mitogen-activated protein kinase 14 / 0.691
3itz P66Mitogen-activated protein kinase 14 / 0.686
3l8x N4DMitogen-activated protein kinase 14 / 0.683
2y6o 1N1Ephrin type-A receptor 4 2.7.10.1 0.682
3iph G11Mitogen-activated protein kinase 14 / 0.681
3bv2 P38Mitogen-activated protein kinase 14 / 0.671
3d7z GK5Mitogen-activated protein kinase 14 / 0.670
3gcv SS6Mitogen-activated protein kinase 14 / 0.670
3hv4 L51Mitogen-activated protein kinase 14 / 0.670
3bv3 P39Mitogen-activated protein kinase 14 / 0.668
2gfs PQBMitogen-activated protein kinase 14 / 0.666
1wbv LI3Mitogen-activated protein kinase 14 / 0.659
4tyj 0LIFibroblast growth factor receptor 4 2.7.10.1 0.658
3dt1 P40Mitogen-activated protein kinase 14 / 0.657
3gcu R48Mitogen-activated protein kinase 14 / 0.655
4v01 0LIFibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b / 0.652
3srq Q19Dihydrofolate reductase 1.5.1.3 0.651