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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2ylt FAD Phenylacetone monooxygenase 1.14.13.92

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2ylt FADPhenylacetone monooxygenase 1.14.13.92 1.434
2ylr FADPhenylacetone monooxygenase 1.14.13.92 1.354
4d04 FADPhenylacetone monooxygenase 1.14.13.92 1.341
2ylx FADPhenylacetone monooxygenase 1.14.13.92 1.312
2yls FADPhenylacetone monooxygenase 1.14.13.92 1.311
4d03 FADPhenylacetone monooxygenase 1.14.13.92 1.283
2ym2 FADPhenylacetone monooxygenase 1.14.13.92 1.242
2ym1 FADPhenylacetone monooxygenase 1.14.13.92 1.166
2ylw FADPhenylacetone monooxygenase 1.14.13.92 1.149
3gwd FADCyclohexanone monooxygenase / 0.925
3up5 FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.924
3uoz FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.917
3up4 FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.852
3uoy FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.841
1w4x FADPhenylacetone monooxygenase 1.14.13.92 0.810
2ylz FADPhenylacetone monooxygenase 1.14.13.92 0.804
3uov FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.804
3gwf FADCyclohexanone monooxygenase / 0.792
5g3t FDAFlavin-dependent L-tryptophan oxidase VioA / 0.791
2vq7 FADPutative flavin-containing monooxygenase / 0.787
2rgh FADAlpha-Glycerophosphate Oxidase / 0.786
2xls FADPutative flavin-containing monooxygenase / 0.774
2xve FADPutative flavin-containing monooxygenase / 0.773
1e1l FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.770
1e1m FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.770
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.768
3qvr FADGlucose oxidase 1.1.3.4 0.766
2gvc FADThiol-specific monooxygenase 1.14.13 0.761
3cty FADProbable thioredoxin reductase / 0.756
2gv8 FADThiol-specific monooxygenase 1.14.13 0.743
4z26 FADPutative GMC-type oxidoreductase R135 1 0.743
3uox FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.740
1rp0 AHZThiamine thiazole synthase, chloroplastic / 0.738
4aox FADSteroid monooxygenase / 0.736
1m6i FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.734
2vqb FADPutative flavin-containing monooxygenase / 0.734
2xlr FADPutative flavin-containing monooxygenase / 0.730
1lqu FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.729
1e6e FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.719
2jae FADL-amino acid oxidase / 0.718
4b63 FADL-ornithine N(5)-monooxygenase / 0.718
3b6d FAECholesterol oxidase 1.1.3.6 0.717
4em4 FADCoenzyme A disulfide reductase / 0.715
1d4c FADFumarate reductase flavoprotein subunit 1.3.5.4 0.713
1get FADGlutathione reductase 1.8.1.7 0.713
4udq FAD5-(hydroxymethyl)furfural oxidase / 0.713
2xvh FADPutative flavin-containing monooxygenase / 0.712
2vvl FADMonoamine oxidase N 1.4.3.4 0.711
3ad9 NADSubunit alpha of sarocosine oxidase / 0.710
2jb2 FADL-amino acid oxidase / 0.708
3ada NADSubunit alpha of sarocosine oxidase / 0.708
2fjd SFDAdenylylsulfate reductase, subunit A (AprA) / 0.706
4z24 FADPutative GMC-type oxidoreductase R135 1 0.705
1b8s FADCholesterol oxidase 1.1.3.6 0.703
2xvi FADPutative flavin-containing monooxygenase / 0.703
4b69 FADL-ornithine N(5)-monooxygenase / 0.703
4fwj FADLysine-specific histone demethylase 1B 1 0.701
4udr FAD5-(hydroxymethyl)furfural oxidase / 0.701
3nlc FADUncharacterized protein / 0.700
2gew FADCholesterol oxidase 1.1.3.6 0.699
3icr FADCoenzyme A disulfide reductase / 0.699
1e1n FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.698
2tmd ADPTrimethylamine dehydrogenase 1.5.8.2 0.698
3qvp FADGlucose oxidase 1.1.3.4 0.698
4mih FADPyranose 2-oxidase 1.1.3.10 0.698
4em3 FADCoenzyme A disulfide reductase / 0.697
4gde FDAUDP-galactopyranose mutase / 0.697
3s5w FADL-ornithine N(5)-monooxygenase / 0.695
3fg2 FADPutative rubredoxin reductase / 0.694
3gyi FADCholesterol oxidase 1.1.3.6 0.694
3ute FADUDP-galactopyranose mutase / 0.694
4u2s FDACholesterol oxidase 1.1.3.6 0.694
3gyj FADCholesterol oxidase 1.1.3.6 0.693
4b64 FADL-ornithine N(5)-monooxygenase / 0.693
4fwf FADLysine-specific histone demethylase 1B 1 0.693
2xlp FADPutative flavin-containing monooxygenase / 0.692
3pl8 FADPyranose 2-oxidase / 0.692
4u2t FADCholesterol oxidase 1.1.3.6 0.691
1cjc FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.689
4qi7 FADCellobiose dehydrogenase / 0.689
3cnj FADCholesterol oxidase 1.1.3.6 0.688
3hdy FADUDP-galactopyranose mutase / 0.688
3ish FADThioredoxin reductase 1.8.1.9 0.688
3k30 ADPHistamine dehydrogenase / 0.688
1gal FADGlucose oxidase 1.1.3.4 0.687
1jnz FADAdenylylsulfate reductase, subunit A (AprA) / 0.687
3lxd FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 0.687
1v0j FADUDP-galactopyranose mutase 5.4.99.9 0.686
2ign FADPyranose 2-oxidase / 0.686
2q7v FADThioredoxin reductase / 0.686
1cf3 FADGlucose oxidase 1.1.3.4 0.685
2yr4 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.685
2fje FADAdenylylsulfate reductase, subunit A (AprA) / 0.682
4fwe FADLysine-specific histone demethylase 1B 1 0.682
4yry FADGlutamate synthase, beta subunit / 0.682
1djn ADPTrimethylamine dehydrogenase 1.5.8.2 0.681
3t14 FADSulfide-quinone reductase / 0.680
4bv6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.680
2fjb SFDAdenylylsulfate reductase, subunit A (AprA) / 0.679
4aos FADSteroid monooxygenase / 0.679
4lii FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.678
2xvf FADPutative flavin-containing monooxygenase / 0.677
3cox FADCholesterol oxidase 1.1.3.6 0.677
2jb1 FADL-amino acid oxidase / 0.676
3lsi FADPyranose 2-oxidase / 0.676
2yr5 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.675
4eqw FADCoenzyme A disulfide reductase / 0.674
4tm3 FADKtzI / 0.674
4u2l SFDCholesterol oxidase 1.1.3.6 0.674
1nhq FADNADH peroxidase 1.11.1.1 0.673
3gd3 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.673
4ap3 FADSteroid monooxygenase / 0.673
2v3a FADRubredoxin-NAD(+) reductase 1.18.1.1 0.671
1o94 ADPTrimethylamine dehydrogenase 1.5.8.2 0.670
2r9z FADGlutathione amide reductase / 0.670
3djj FADGlutathione reductase, mitochondrial 1.8.1.7 0.670
3he3 FADUDP-galactopyranose mutase / 0.670
3kkj FADRenalase / 0.670
3q9t FAYUncharacterized protein / 0.670
3t37 FADPyridoxine 4-oxidase / 0.670
3ef6 FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.669
5cku FADL-ornithine N(5)-monooxygenase / 0.669
1d4d FADFumarate reductase flavoprotein subunit 1.3.5.4 0.668
1djq ADPTrimethylamine dehydrogenase 1.5.8.2 0.668
1joa FADNADH peroxidase 1.11.1.1 0.668
3bi5 FADPolyamine oxidase FMS1 / 0.668
4gut FADLysine-specific histone demethylase 1B 1 0.668
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.667
1h81 FADPolyamine oxidase 1.5.3.14 0.666
4ap1 FADSteroid monooxygenase / 0.666
1gsn FADGlutathione reductase, mitochondrial 1.8.1.7 0.665
3mj4 FADUDP-galactopyranose mutase / 0.665
4h4r FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.665
1ps9 FAD2,4-dienoyl-CoA reductase 1.3.1.34 0.664
1trb FADThioredoxin reductase 1.8.1.9 0.663
2fja FADAdenylylsulfate reductase, subunit A (AprA) / 0.663
2r0c FADPutative FAD-monooxygenase / 0.663
4h4t FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.663
1d7y FADFerredoxin reductase / 0.662
2c7g FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.662
2wet FADTryptophan 5-halogenase / 0.662
3f8r NAPNADH oxidase/thioredoxin reductase / 0.662
3rha FDAPutrescine oxidase / 0.662
3sz0 FADSulfide-quinone reductase / 0.662
1jnr FADAdenylylsulfate reductase, subunit A (AprA) / 0.661
1e1k FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.660
1tdk FADL-amino-acid oxidase 1.4.3.2 0.660
1yqz FADCoenzyme A disulfide reductase / 0.660
3f8p NADNADH oxidase/thioredoxin reductase / 0.660
3ukl FADUDP-galactopyranose mutase / 0.660
4dsg FADUncharacterized protein / 0.660
4ynt FDAGlucose oxidase, putative / 0.660
1gra FADGlutathione reductase, mitochondrial 1.8.1.7 0.659
3pvc FADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC / 0.659
4h4p FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.659
3h5n ATPMccB protein / 0.658
3lsm SFDPyranose 2-oxidase / 0.658
5eb5 FAD(R)-mandelonitrile lyase 1 4.1.2.10 0.658
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.657
1zmc NADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.657
3cge FADCoenzyme A disulfide reductase / 0.657
5hhf FDAUDP-galactopyranose mutase / 0.657
2bab FADPutative aminooxidase / 0.656
3t2y FADSulfide-quinone reductase / 0.656
4i58 FADCyclohexylamine Oxidase / 0.656
4txi FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.656
4gdd FADUDP-galactopyranose mutase / 0.655
4u8p FDAUDP-galactopyranose mutase / 0.655
2igo FADPyranose 2-oxidase / 0.654
4h4x FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.654
4o5u FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.654
4ttc FMNIodotyrosine deiodinase 1 / 0.654
3bi2 FADPolyamine oxidase FMS1 / 0.653
4h4v FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.653
4hsu FADLysine-specific histone demethylase 1B 1 0.653
4usr FADMonooxygenase / 0.653
5br7 FADUDP-galactopyranose mutase / 0.653
3cgb FADCoenzyme A disulfide reductase / 0.651
3cgc FADCoenzyme A disulfide reductase / 0.651
2b9w FADPutative aminooxidase / 0.650
4b68 FADL-ornithine N(5)-monooxygenase / 0.650