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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2yja EST Estrogen receptor

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2yja ESTEstrogen receptor / 1.179
3uud ESTEstrogen receptor / 1.128
4pxm ESTEstrogen receptor / 1.122
3l03 4OHEstrogen receptor / 1.102
1gwr ESTEstrogen receptor / 1.070
5dxg ESTEstrogen receptor / 1.069
5hyr ESTEstrogen receptor / 1.067
3q95 ESLEstrogen receptor / 1.046
5dx3 ESTEstrogen receptor / 1.009
2g5o DRQEstrogen receptor / 1.008
2b1z 17MEstrogen receptor / 1.000
3oll ESTEstrogen receptor beta / 0.990
2ocf ESTEstrogen receptor / 0.952
2yat EEUEstrogen receptor / 0.937
2j7x ESTEstrogen receptor beta / 0.919
1g50 ESTEstrogen receptor / 0.902
2q70 DC8Estrogen receptor / 0.784
1i5r HYCEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.746
1x7e 244Estrogen receptor / 0.736
3ols ESTEstrogen receptor beta / 0.732
4j24 ESTEstrogen receptor beta / 0.725
3s79 ASDAromatase 1.14.14.14 0.716
2qgt EEDEstrogen receptor / 0.714
3gki CLRNiemann-Pick C1 protein / 0.711
4oez DHTAndrogen receptor / 0.711
2qe4 JJ3Estrogen receptor / 0.708
4pp6 STLEstrogen receptor / 0.701
4j26 ESTEstrogen receptor beta / 0.698
2pog WSTEstrogen receptor / 0.697
4oey DHTAndrogen receptor / 0.697
2pix DHTAndrogen receptor / 0.691
5l7d CLRSmoothened homolog / 0.690
4ofr DHTAndrogen receptor / 0.688
1p8d CO1Oxysterols receptor LXR-beta / 0.685
3w5p 4OAVitamin D3 receptor / 0.685
1aqu ESTEstrogen sulfotransferase, testis isoform 2.8.2.4 0.684
3cas ASD3-oxo-5-beta-steroid 4-dehydrogenase / 0.681
3bej MUFBile acid receptor / 0.680
2aa5 STRMineralocorticoid receptor / 0.676
1lho AOMSex hormone-binding globulin / 0.675
1t79 DHTAndrogen receptor / 0.673
1lhu ESTSex hormone-binding globulin / 0.672
4oea DHTAndrogen receptor / 0.672
2piu DHTAndrogen receptor / 0.671
4y8w STRSteroid 21-hydroxylase / 0.670
1lhw ESMSex hormone-binding globulin / 0.665
2ao6 R18Androgen receptor / 0.664
3cot STR3-oxo-5-beta-steroid 4-dehydrogenase / 0.662
4jvl ESTEstrogen sulfotransferase 2.8.2.4 0.662
1zky 689Estrogen receptor / 0.661
2jn3 JN3Fatty acid-binding protein, liver / 0.661
4e5f 0N7Polymerase acidic protein / 0.661
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.660
4e5i 0N9Polymerase acidic protein / 0.660
4j6b PLOCytochrome P450 monooxygenase / 0.658
4nky 3QZSteroid 17-alpha-hydroxylase/17,20 lyase / 0.658
1ya3 STRMineralocorticoid receptor / 0.657
2pip DHTAndrogen receptor / 0.656
2q7k TESAndrogen receptor / 0.656
2v95 HCYCorticosteroid-binding globulin / 0.656
3iw1 ASDSteroid C26-monooxygenase 1.14.13.141 0.654
2ipj FFAAldo-keto reductase family 1 member C2 / 0.653
2rlc CHDCholoylglycine hydrolase 3.5.1.24 0.653
4ofu DHTAndrogen receptor / 0.652
1xf0 ASDAldo-keto reductase family 1 member C3 / 0.650