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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2yiw YIW Mitogen-activated protein kinase 14

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2yiw YIWMitogen-activated protein kinase 14 / 1.325
2yis YISMitogen-activated protein kinase 14 / 1.171
3hv7 1AUMitogen-activated protein kinase 14 / 0.983
3p7b P7BMitogen-activated protein kinase 14 / 0.965
3p5k P5KMitogen-activated protein kinase 14 / 0.964
3nnx EDDMitogen-activated protein kinase 14 / 0.946
3npc B96Mitogen-activated protein kinase 9 2.7.11.24 0.932
3nnw EDDMitogen-activated protein kinase 14 / 0.874
1kv2 B96Mitogen-activated protein kinase 14 / 0.871
2puu G2GMitogen-activated protein kinase 14 / 0.870
3hv6 R39Mitogen-activated protein kinase 14 / 0.870
1w82 L10Mitogen-activated protein kinase 14 / 0.862
3uvr 06FMitogen-activated protein kinase 14 / 0.828
3p7a P7AMitogen-activated protein kinase 14 / 0.813
3hv3 R49Mitogen-activated protein kinase 14 / 0.807
3p7c P7CMitogen-activated protein kinase 14 / 0.801
2yix YIXMitogen-activated protein kinase 14 / 0.800
3gcq 1BUMitogen-activated protein kinase 14 / 0.795
4f6w 0SSCyclin-dependent kinase 8 2.7.11.22 0.791
4f7n 0SVCyclin-dependent kinase 8 2.7.11.22 0.787
3gi3 B10Mitogen-activated protein kinase 14 / 0.777
3lfb Z87Mitogen-activated protein kinase 14 / 0.776
4f7j 0SUCyclin-dependent kinase 8 2.7.11.22 0.775
3hv5 R24Mitogen-activated protein kinase 14 / 0.765
4f6s 0SQCyclin-dependent kinase 8 2.7.11.22 0.755
4k9y K9YFocal adhesion kinase 1 2.7.10.2 0.755
4f7l 0SOCyclin-dependent kinase 8 2.7.11.22 0.745
3hv4 L51Mitogen-activated protein kinase 14 / 0.741
4kao KAOFocal adhesion kinase 1 2.7.10.2 0.724
3gcv SS6Mitogen-activated protein kinase 14 / 0.720
3nww 3NWMitogen-activated protein kinase 14 / 0.718
4twn B96Ephrin type-A receptor 3 2.7.10.1 0.717
4h1m 0YJProtein-tyrosine kinase 2-beta 2.7.10.2 0.715
3fzt 4JZProtein-tyrosine kinase 2-beta 2.7.10.2 0.713
3p79 P79Mitogen-activated protein kinase 14 / 0.705
3lfe Z84Mitogen-activated protein kinase 14 / 0.704
3o8t BMUMitogen-activated protein kinase 14 / 0.704
3qri 919Tyrosine-protein kinase ABL1 2.7.10.2 0.702
3gcu R48Mitogen-activated protein kinase 14 / 0.693
4h1j 0YHProtein-tyrosine kinase 2-beta 2.7.10.2 0.691
3oc1 BMUMitogen-activated protein kinase 14 / 0.680
3vhe 42QVascular endothelial growth factor receptor 2 2.7.10.1 0.678
4ase AV9Vascular endothelial growth factor receptor 2 2.7.10.1 0.676
3lff Z83Mitogen-activated protein kinase 14 / 0.675
3p78 P78Mitogen-activated protein kinase 14 / 0.675
4f70 0STCyclin-dependent kinase 8 2.7.11.22 0.675
3pg3 DG7Mitogen-activated protein kinase 14 / 0.669
3e92 G6AMitogen-activated protein kinase 14 / 0.665
3fzs B96Protein-tyrosine kinase 2-beta 2.7.10.2 0.665
4eh5 0OMMitogen-activated protein kinase 14 / 0.664
3o8u BMUMitogen-activated protein kinase 14 / 0.662
3gcs BAXMitogen-activated protein kinase 14 / 0.654
4uxq 0LIFibroblast growth factor receptor 4 2.7.10.1 0.652