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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2yfx VGH ALK tyrosine kinase receptor 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2yfx VGHALK tyrosine kinase receptor 2.7.10.1 0.988
4anq VGHALK tyrosine kinase receptor 2.7.10.1 0.962
4ans VGHALK tyrosine kinase receptor 2.7.10.1 0.953
2xp2 VGHALK tyrosine kinase receptor 2.7.10.1 0.945
5aac VGHALK tyrosine kinase receptor 2.7.10.1 0.944
5aaa VGHALK tyrosine kinase receptor 2.7.10.1 0.935
5aab VGHALK tyrosine kinase receptor 2.7.10.1 0.906
4cd0 AWJALK tyrosine kinase receptor 2.7.10.1 0.790
4ccu AWFALK tyrosine kinase receptor 2.7.10.1 0.769
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
3zls 92PDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.685
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.670
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.660
4e5f 0N7Polymerase acidic protein / 0.660
1xxj UNCUricase 1.7.3.3 0.653