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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2ycn P61 Tyrosine phenol-lyase 4.1.99.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2ycn P61Tyrosine phenol-lyase 4.1.99.2 1.395
1cl2 PPGCystathionine beta-lyase MetC 4.4.1.8 0.746
4wxg 2BOSerine hydroxymethyltransferase / 0.718
4d96 5PAD-cysteine desulfhydrase / 0.705
4d9f DCSD-cysteine desulfhydrase / 0.705
3aej AA5Methionine gamma-lyase / 0.704
3qpg 3QPAspartate aminotransferase 2.6.1.1 0.691
4w5k PLPAspartate aminotransferase, mitochondrial / 0.688
4wlj IK2Kynurenine--oxoglutarate transaminase 1 2.6.1.7 0.680
1akb PPDAspartate aminotransferase, mitochondrial 2.6.1.1 0.677
4jey PLPAcetylornithine/succinyldiaminopimelate aminotransferase 2.6.1.11 0.668
4kqs RISFarnesyl pyrophosphate synthase 2.5.1.10 0.668
4gdy 0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial 2.6.1.39 0.666
1ivr CBAAspartate aminotransferase, mitochondrial 2.6.1.1 0.657
2fto TMPThymidylate synthase / 0.656
1wkh PPE[LysW]-aminoadipate semialdehyde transaminase / 0.651
5k8b PDG8-amino-3,8-dideoxy-alpha-D-manno-octulosonate transaminase / 0.651