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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2xyn VX6 Abelson tyrosine-protein kinase 2 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2xyn VX6Abelson tyrosine-protein kinase 2 2.7.10.2 1.117
2f4j VX6Tyrosine-protein kinase ABL1 2.7.10.2 0.785
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4f64 0S8Fibroblast growth factor receptor 1 / 0.701
4af3 VX6Aurora kinase B 2.7.11.1 0.690
2xa4 AZ5Tyrosine-protein kinase JAK2 / 0.683
4c61 LMMTyrosine-protein kinase JAK2 / 0.683
4f63 0S7Fibroblast growth factor receptor 1 / 0.676
3amb VX6cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.668
3e5a VX6Aurora kinase A 2.7.11.1 0.668
4jbq VX6Aurora kinase A 2.7.11.1 0.668
4bdh WVISerine/threonine-protein kinase Chk2 2.7.11.1 0.664
2v7a 627Tyrosine-protein kinase ABL1 2.7.10.2 0.663
4e5f 0N7Polymerase acidic protein / 0.660
2j4z 626Aurora kinase A 2.7.11.1 0.650