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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2xw7 NDP Dihydrofolate reductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2xw7 NDPDihydrofolate reductase / 1.229
1dr3 TAPDihydrofolate reductase 1.5.1.3 0.746
1rx1 NAPDihydrofolate reductase 1.5.1.3 0.738
8dfr NDPDihydrofolate reductase 1.5.1.3 0.732
3dga NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.729
1ra3 NAPDihydrofolate reductase 1.5.1.3 0.727
1dr2 TAPDihydrofolate reductase 1.5.1.3 0.721
1dr5 NAPDihydrofolate reductase 1.5.1.3 0.721
3nxx NDPDihydrofolate reductase 1.5.1.3 0.711
4m6j NDPDihydrofolate reductase 1.5.1.3 0.710
1ia1 NDPDihydrofolate reductase 1.5.1.3 0.703
2w3b NDPDihydrofolate reductase 1.5.1.3 0.695
2cig 1DGDihydrofolate reductase 1.5.1.3 0.674
1m78 NDPDihydrofolate reductase 1.5.1.3 0.670
3clb NAPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.669
2d5n NDPRiboflavin biosynthesis protein RibD 1.1.1.193 0.666
1rx6 NAPDihydrofolate reductase 1.5.1.3 0.656