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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2xm9 LWH Serine/threonine-protein kinase Chk2 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2xm9 LWHSerine/threonine-protein kinase Chk2 2.7.11.1 1.117
2xbj XBJSerine/threonine-protein kinase Chk2 2.7.11.1 0.805
4ftl H0KSerine/threonine-protein kinase Chk1 2.7.11.1 0.689
2fum MIXSerine/threonine-protein kinase PknB 2.7.11.1 0.672
2vag V25Dual specificity protein kinase CLK1 2.7.12.1 0.671
4fsr HKCSerine/threonine-protein kinase Chk1 2.7.11.1 0.661
3oog YTPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.658
1gm7 PNNPenicillin G acylase 3.5.1.11 0.653
2uzt SS3cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.652
1pmu 9HPMitogen-activated protein kinase 10 2.7.11.24 0.651
4ap7 F47Hepatocyte growth factor receptor 2.7.10.1 0.651