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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2xk3 XK3 Serine/threonine-protein kinase Nek2 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2xk3 XK3Serine/threonine-protein kinase Nek2 2.7.11.1 1.024
2xk6 EQHSerine/threonine-protein kinase Nek2 2.7.11.1 0.867
2xke WI2Serine/threonine-protein kinase Nek2 2.7.11.1 0.858
2xkf BX1Serine/threonine-protein kinase Nek2 2.7.11.1 0.814
2xkd T3MSerine/threonine-protein kinase Nek2 2.7.11.1 0.772
2wqo VGKSerine/threonine-protein kinase Nek2 2.7.11.1 0.764
2xkc 4VQSerine/threonine-protein kinase Nek2 2.7.11.1 0.762
2xk4 OL2Serine/threonine-protein kinase Nek2 2.7.11.1 0.702
2xk8 5R1Serine/threonine-protein kinase Nek2 2.7.11.1 0.701
4a4x JUPSerine/threonine-protein kinase Nek2 2.7.11.1 0.665
4fa3 0SLAldo-keto reductase family 1 member C3 / 0.663
3bgz VX3Serine/threonine-protein kinase pim-1 2.7.11.1 0.660
2e9o A58Serine/threonine-protein kinase Chk1 2.7.11.1 0.652
2v4l ABJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 2.7.1.153 0.651
2xk9 XK9Serine/threonine-protein kinase Chk2 2.7.11.1 0.650