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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2xik J60 Serine/threonine-protein kinase 25 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2xik J60Serine/threonine-protein kinase 25 2.7.11.1 0.895
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
3l9l L9LcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.688
2x2l X2LProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.687
2y7j B49Phosphorylase b kinase gamma catalytic chain, liver/testis isoform 2.7.11.19 0.685
1q41 IXMGlycogen synthase kinase-3 beta 2.7.11.26 0.682
2pe0 39Z3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.681
4qmt H1NSerine/threonine-protein kinase 24 2.7.11.1 0.677
2jam J60Calcium/calmodulin-dependent protein kinase type 1G 2.7.11.17 0.669
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.668
1v0o INRCell division control protein 2 homolog 2.7.11.22 0.666
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.666
2x2k X2KProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.666
4ks8 B49Serine/threonine-protein kinase PAK 6 2.7.11.1 0.665
1fvt 106Cyclin-dependent kinase 2 2.7.11.22 0.664
2pe1 5173-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.661
1ke9 LS5Cyclin-dependent kinase 2 2.7.11.22 0.660
4e5f 0N7Polymerase acidic protein / 0.660
4jlc SU6Serine/threonine-protein kinase TBK1 2.7.11.1 0.659
2hy0 306Serine/threonine-protein kinase Chk1 2.7.11.1 0.658
2x2m X2MProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.652
4fsr HKCSerine/threonine-protein kinase Chk1 2.7.11.1 0.652
2qkr IXMCdc2-like CDK2/CDC28 like protein kinase / 0.651
4agd B49Vascular endothelial growth factor receptor 2 2.7.10.1 0.651
4fsq HK3Serine/threonine-protein kinase Chk1 2.7.11.1 0.651