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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2xck MH4 3-phosphoinositide-dependent protein kinase 1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2xck MH43-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.970
2xch CKG3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.817
3bea IXHMacrophage colony-stimulating factor 1 receptor 2.7.10.1 0.724
1z5m LI83-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.723
4eut BX7Serine/threonine-protein kinase TBK1 2.7.11.1 0.705
2wxv WXVCyclin-dependent kinase 2 2.7.11.22 0.704
3i60 E86Mitogen-activated protein kinase 1 2.7.11.24 0.697
4fv6 E57Mitogen-activated protein kinase 1 2.7.11.24 0.691
2jkq VG8Focal adhesion kinase 1 2.7.10.2 0.690
2p33 J07Mitogen-activated protein kinase 10 2.7.11.24 0.690
3cjf SAVVascular endothelial growth factor receptor 2 2.7.10.1 0.689
2hxl 422Serine/threonine-protein kinase Chk1 2.7.11.1 0.687
2wip P49Cyclin-dependent kinase 2 2.7.11.22 0.684
4a4o 664Serine/threonine-protein kinase PLK1 2.7.11.21 0.684
1oec AA2Fibroblast growth factor receptor 2 / 0.682
4f64 0S8Fibroblast growth factor receptor 1 / 0.682
2x6d X6DAurora kinase A 2.7.11.1 0.681
4bgh 3I6Cyclin-dependent kinase 2 2.7.11.22 0.680
1q8u H52cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.677
3cgo JNOMitogen-activated protein kinase 10 2.7.11.24 0.677
2qhn 582Serine/threonine-protein kinase Chk1 2.7.11.1 0.674
2hog 710Serine/threonine-protein kinase Chk1 2.7.11.1 0.673
3cjg KIMVascular endothelial growth factor receptor 2 2.7.10.1 0.670
2xb7 GUIALK tyrosine kinase receptor 2.7.10.1 0.669
1gij 2PUCyclin-dependent kinase 2 2.7.11.22 0.667
2x81 ZZLAurora kinase A 2.7.11.1 0.666
2x1n X1NCyclin-dependent kinase 2 2.7.11.22 0.665
1oit HDTCyclin-dependent kinase 2 2.7.11.22 0.664
3uli 1N3Cyclin-dependent kinase 2 2.7.11.22 0.663
3uo5 0BXAurora kinase A 2.7.11.1 0.663
4e93 GUITyrosine-protein kinase Fes/Fps 2.7.10.2 0.663
3tki S25Serine/threonine-protein kinase Chk1 2.7.11.1 0.661
2hy0 306Serine/threonine-protein kinase Chk1 2.7.11.1 0.660
3efw AK8Aurora kinase A 2.7.11.1 0.660
2wmx ZY6Serine/threonine-protein kinase Chk1 2.7.11.1 0.659
2xnb Y8LCyclin-dependent kinase 2 2.7.11.22 0.652
4nka 2K7Fibroblast growth factor receptor 1 / 0.652