Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2xba 571 ALK tyrosine kinase receptor 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2xba 571ALK tyrosine kinase receptor 2.7.10.1 0.974
2j50 627Aurora kinase A 2.7.11.1 0.779
2v7a 627Tyrosine-protein kinase ABL1 2.7.10.2 0.757
4aoj V4ZHigh affinity nerve growth factor receptor 2.7.10.1 0.728
2j4z 626Aurora kinase A 2.7.11.1 0.712
2bmc MPYAurora kinase A 2.7.11.1 0.669
2vn9 GVDCalcium/calmodulin-dependent protein kinase type II subunit delta 2.7.11.17 0.669
4qo9 627Serine/threonine-protein kinase 24 2.7.11.1 0.669
5aaa VGHALK tyrosine kinase receptor 2.7.10.1 0.655
3lfn A27Cyclin-dependent kinase 2 2.7.11.22 0.653
3ggf GVDSerine/threonine-protein kinase 26 / 0.650