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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2x2k X2K Proto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2x2k X2KProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.892
2x2m X2MProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.836
2x2l X2LProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.780
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
3g0f B49Mast/stem cell growth factor receptor Kit 2.7.10.1 0.727
2pe2 4643-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.709
2y7j B49Phosphorylase b kinase gamma catalytic chain, liver/testis isoform 2.7.11.19 0.698
2pe1 5173-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.692
2jav 5Z5Serine/threonine-protein kinase Nek2 2.7.11.1 0.683
3hzt J60Calmodulin-like domain protein kinase isoform 3 / 0.683
2qkr IXMCdc2-like CDK2/CDC28 like protein kinase / 0.677
2hxq 373Serine/threonine-protein kinase Chk1 2.7.11.1 0.676
2vz6 FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha 2.7.11.17 0.676
2pe0 39Z3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.675
3g0e B49Mast/stem cell growth factor receptor Kit 2.7.10.1 0.675
4jlc SU6Serine/threonine-protein kinase TBK1 2.7.11.1 0.675
2bfy H1NAurora kinase B-A 2.7.11.1 0.674
3l9l L9LcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.673
2hy0 306Serine/threonine-protein kinase Chk1 2.7.11.1 0.672
4aw5 30KEphrin type-B receptor 4 2.7.10.1 0.670
3ezv EZVCyclin-dependent kinase 2 2.7.11.22 0.668
4fks 46KCyclin-dependent kinase 2 2.7.11.22 0.668
4fkv 61KCyclin-dependent kinase 2 2.7.11.22 0.668
1q41 IXMGlycogen synthase kinase-3 beta 2.7.11.26 0.666
2xik J60Serine/threonine-protein kinase 25 2.7.11.1 0.666
4fkr 45KCyclin-dependent kinase 2 2.7.11.22 0.665
4qmz B49Serine/threonine-protein kinase 24 2.7.11.1 0.665
1ke9 LS5Cyclin-dependent kinase 2 2.7.11.22 0.663
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.661
4e5f 0N7Polymerase acidic protein / 0.660
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.658
2hog 710Serine/threonine-protein kinase Chk1 2.7.11.1 0.655
3c7q XINVascular endothelial growth factor receptor 2 2.7.10.1 0.655
3ti1 B49Cyclin-dependent kinase 2 2.7.11.22 0.654
4ks8 B49Serine/threonine-protein kinase PAK 6 2.7.11.1 0.653
2m3z 1HFGag-Pol polyprotein / 0.652
4fsu HK5Serine/threonine-protein kinase Chk1 2.7.11.1 0.651
4fkp LS5Cyclin-dependent kinase 2 2.7.11.22 0.650