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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2wtk ANP STE20-related kinase adapter protein alpha

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity
Align
2wtk ANPSTE20-related kinase adapter protein alpha / 1.112
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.733
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.707
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.693
4ffl ADPUncharacterized protein / 0.690
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.682
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.681
4ceg ADPAurora kinase A 2.7.11.1 0.680
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.678
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.670
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.668
2dwb ANPAurora kinase A 2.7.11.1 0.667
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.667
1cm8 ANPMitogen-activated protein kinase 12 / 0.666
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.666
1ol5 ADPAurora kinase A 2.7.11.1 0.666
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.665
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.664
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.664
4o4d ATPKinase / 0.664
5dr2 ATPAurora kinase A 2.7.11.1 0.664
2vuw 5IDSerine/threonine-protein kinase haspin 2.7.11.1 0.662
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.661
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.660
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.660
4q5h ANPProtein kinase OspG 2.7 0.660
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.660
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.659
2p0a ANPSynapsin-3 / 0.659
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.659
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.658
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.657
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.657
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.657
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.656
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.654
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.652
5cu6 ATPCasein kinase II subunit alpha 2.7.11.1 0.652
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.651
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.650
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.650
4mam A12N5-carboxyaminoimidazole ribonucleotide synthase / 0.650
4xlv ACPInsulin receptor 2.7.10.1 0.650