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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2wou ZZF TGF-beta receptor type-1 2.7.11.30

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2wou ZZFTGF-beta receptor type-1 2.7.11.30 1.057
2wot ZZGTGF-beta receptor type-1 2.7.11.30 0.897
2x9f X9FEphrin type-B receptor 4 2.7.10.1 0.703
2xvd AS6Ephrin type-B receptor 4 2.7.10.1 0.688
1vjy 460TGF-beta receptor type-1 2.7.11.30 0.683
2vwx 7X4Ephrin type-B receptor 4 2.7.10.1 0.682
5bvw 1N1Epithelial discoidin domain-containing receptor 1 2.7.10.1 0.677
4mxy DB8Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.673
4mxz DB8Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.673
3mtf A3FActivin receptor type-1 2.7.11.30 0.653
2itt AEEEpidermal growth factor receptor 2.7.10.1 0.651