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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2wf4 ZY4 Beta-secretase 1 3.4.23.46

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2wf4 ZY4Beta-secretase 1 3.4.23.46 1.227
2vj9 VG7Beta-secretase 1 3.4.23.46 1.089
2vj6 VG5Beta-secretase 1 3.4.23.46 1.058
2vnn CM7Beta-secretase 1 3.4.23.46 1.056
2vij C44Beta-secretase 1 3.4.23.46 1.049
2wf1 ZY1Beta-secretase 1 3.4.23.46 1.043
2vnm CM8Beta-secretase 1 3.4.23.46 1.037
2xfj VG5Beta-secretase 1 3.4.23.46 1.028
2wf2 ZY2Beta-secretase 1 3.4.23.46 1.024
2b8l 5HABeta-secretase 1 3.4.23.46 1.023
2vie VG0Beta-secretase 1 3.4.23.46 1.015
2xfk AA9Beta-secretase 1 3.4.23.46 1.010
2viz VG4Beta-secretase 1 3.4.23.46 1.009
2b8v 3BNBeta-secretase 1 3.4.23.46 1.006
2vj7 VG6Beta-secretase 1 3.4.23.46 1.006
2wf3 ZY3Beta-secretase 1 3.4.23.46 1.003
2p8h MY9Beta-secretase 1 3.4.23.46 0.995
2wez ZYEBeta-secretase 1 3.4.23.46 0.995
4fco 0U4Beta-secretase 1 3.4.23.46 0.993
2wf0 ZY0Beta-secretase 1 3.4.23.46 0.977
2xfi XFIBeta-secretase 1 3.4.23.46 0.962
2viy VG3Beta-secretase 1 3.4.23.46 0.945
3ixj 586Beta-secretase 1 3.4.23.46 0.884
4dpf 0LGBeta-secretase 1 3.4.23.46 0.875
3k5g BJCBeta-secretase 1 3.4.23.46 0.872
3k5c 0BIBeta-secretase 1 3.4.23.46 0.871
3i25 MV7Beta-secretase 1 3.4.23.46 0.865
2iqg F2IBeta-secretase 1 3.4.23.46 0.862
3dm6 757Beta-secretase 1 3.4.23.46 0.851
3cib 314Beta-secretase 1 3.4.23.46 0.834
4dus 0MPBeta-secretase 1 3.4.23.46 0.834
3ohf 3HFBeta-secretase 1 3.4.23.46 0.828
2p83 MR0Beta-secretase 1 3.4.23.46 0.824
3nsh 957Beta-secretase 1 3.4.23.46 0.822
4i0i 957Beta-secretase 1 3.4.23.46 0.822
4k9h 1QUBeta-secretase 1 3.4.23.46 0.815
2hiz LIJBeta-secretase 1 3.4.23.46 0.811
4gid 0GHBeta-secretase 1 3.4.23.46 0.802
4dpi 0N1Beta-secretase 1 3.4.23.46 0.801
2qzl IXSBeta-secretase 1 3.4.23.46 0.797
3cic 316Beta-secretase 1 3.4.23.46 0.793
3lpk Z76Beta-secretase 1 3.4.23.46 0.792
4i0j 842Beta-secretase 1 3.4.23.46 0.787
3ixk 929Beta-secretase 1 3.4.23.46 0.786
3cid 318Beta-secretase 1 3.4.23.46 0.785
3r2f PB0Beta-secretase 1 3.4.23.46 0.784
4ke0 1R8Beta-secretase 1 3.4.23.46 0.780
4k8s 1QTBeta-secretase 1 3.4.23.46 0.766
1w51 L01Beta-secretase 1 3.4.23.46 0.762
3tpr 5HABeta-secretase 1 3.4.23.46 0.762
4dh6 0KNBeta-secretase 1 3.4.23.46 0.762
3dv5 BAVBeta-secretase 1 3.4.23.46 0.760
3qi1 C6ABeta-secretase 1 3.4.23.46 0.734
3vf3 0GSBeta-secretase 1 3.4.23.46 0.725
3n4l 842Beta-secretase 1 3.4.23.46 0.719
3qbh QBHBeta-secretase 1 3.4.23.46 0.719
2p4j 23IBeta-secretase 1 3.4.23.46 0.711
2ph6 712Beta-secretase 1 3.4.23.46 0.688
3dv1 AR9Beta-secretase 1 3.4.23.46 0.687
4ke1 1R6Beta-secretase 1 3.4.23.46 0.682
2fdp FRPBeta-secretase 1 3.4.23.46 0.676
3k5f AYHBeta-secretase 1 3.4.23.46 0.675
2ntr L00Beta-secretase 1 3.4.23.46 0.665
2hm1 LIQBeta-secretase 1 3.4.23.46 0.663
2oah QINBeta-secretase 1 3.4.23.46 0.661
2vkm BSDBeta-secretase 1 3.4.23.46 0.659
4y38 0A9Endothiapepsin 3.4.23.22 0.658
3lpj Z75Beta-secretase 1 3.4.23.46 0.655
4i0h 1BLBeta-secretase 1 3.4.23.46 0.651
1bxo PP7Penicillopepsin-1 3.4.23.20 0.650
2g94 ZPQBeta-secretase 1 3.4.23.46 0.650
2irz I02Beta-secretase 1 3.4.23.46 0.650