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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2wa2 SAM Genome polyprotein

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2wa2 SAMGenome polyprotein / 0.879
3evc SAHGenome polyprotein 2.1.1.56 0.789
3eva SAHGenome polyprotein 2.1.1.56 0.787
3ely SAHMethyltransferase / 0.781
3p8z SAHGenome polyprotein 2.1.1.56 0.767
3eld SFGMethyltransferase / 0.759
1r6a SAHGenome polyprotein 2.7.7.48 0.756
2p41 SAHGenome polyprotein / 0.756
3p97 SAMGenome polyprotein 2.1.1.56 0.743
1l9k SAHGenome polyprotein 2.7.7.48 0.742
2px2 SAHGenome polyprotein 2.7.7.48 0.742
5jjr SAHGenome polyprotein / 0.740
3lkz SFGGenome polyprotein / 0.733
2px5 SAHGenome polyprotein 2.7.7.48 0.722
3evg SAHGenome polyprotein 2.1.1.56 0.722
1wg8 SAMRibosomal RNA small subunit methyltransferase H / 0.721
3evb SAHGenome polyprotein 2.1.1.56 0.720
5dto SAHGenome polyprotein / 0.719
2p3q SAHGenome polyprotein / 0.718
2pxa SAHGenome polyprotein 2.7.7.48 0.718
5k7w SAHN6-adenosine-methyltransferase 70 kDa subunit / 0.715
3elu SAMMethyltransferase / 0.714
4ctk SAMGenome polyprotein / 0.711
4n48 SAMCap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 2.1.1.57 0.711
5il2 SAHN6-adenosine-methyltransferase 70 kDa subunit / 0.711
4ctj SAMGenome polyprotein / 0.708
3vyw SAMUncharacterized protein / 0.705
2pwy SAHtRNA (adenine(58)-N(1))-methyltransferase TrmI 2.1.1.220 0.703
3tos SAHCalS11 / 0.694
5k7u SAMN6-adenosine-methyltransferase 70 kDa subunit / 0.694
5jjs SAHGenome polyprotein / 0.693
4k6m SAHGenome polyprotein / 0.689
3emd SFGMethyltransferase / 0.685
2nyu SAMrRNA methyltransferase 2, mitochondrial / 0.680
2p1d SAHGenome polyprotein 2.7.7.48 0.680
4gf5 SAHCalS11 / 0.673
3p8z 36AGenome polyprotein 2.1.1.56 0.671
3tm5 SFGUncharacterized protein / 0.671
2yxl SFG450aa long hypothetical fmu protein / 0.660
3pt9 SAHDNA (cytosine-5)-methyltransferase 1 2.1.1.37 0.660
1skm SAHModification methylase HhaI 2.1.1.37 0.657
4x7y SAHMycinamicin III 3''-O-methyltransferase 2.1.1.237 0.656
1boo SAHModification methylase PvuII 2.1.1.113 0.651
2i9k SAHModification methylase HhaI 2.1.1.37 0.651
3c3y SAHO-methyltransferase / 0.651
9mht SAHModification methylase HhaI 2.1.1.37 0.651
10mh SAHModification methylase HhaI 2.1.1.37 0.650
2xbm SAHGenome polyprotein / 0.650
2yvl SAMtRNA (adenine(58)-N(1))-methyltransferase TrmI / 0.650