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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2w9h TOP Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2w9h TOPDihydrofolate reductase 1.5.1.3 0.951
3fre TOPDihydrofolate reductase 1.5.1.3 0.765
3fyv XCFDihydrofolate reductase 1.5.1.3 0.755
4elf 35IDihydrofolate reductase / 0.751
3fra I2HDihydrofolate reductase 1.5.1.3 0.746
2w3v TOPDihydrofolate reductase / 0.707
4m7v RARDihydrofolate reductase / 0.699
4elh 53IDihydrofolate reductase / 0.695
4elb 34SDihydrofolate reductase / 0.690
3frf XCFDihydrofolate reductase 1.5.1.3 0.687
3fyw XCFDihydrofolate reductase 1.5.1.3 0.685
4g8z TOPDihydrofolate reductase 1.5.1.3 0.681
1dre MTXDihydrofolate reductase 1.5.1.3 0.678
1dyr TOPDihydrofolate reductase 1.5.1.3 0.675
2w9g TOPDihydrofolate reductase 1.5.1.3 0.665
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.665
4fgg 0U5Dihydrofolate reductase 1.5.1.3 0.658
1dg5 TOPDihydrofolate reductase 1.5.1.3 0.657
1lud TRRDihydrofolate reductase 1.5.1.3 0.652