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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2w8y 486 Progesterone receptor

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2w8y 486Progesterone receptor / 1.347
2w8y NDRProgesterone receptor / 0.951
2ovh AS0Progesterone receptor / 0.907
4a2j AS0Progesterone receptor / 0.903
2ovm AS0Progesterone receptor / 0.867
3vhu SNLMineralocorticoid receptor / 0.795
2aa2 AS4Mineralocorticoid receptor / 0.768
2ab2 SNLMineralocorticoid receptor / 0.760
2abi 1CAMineralocorticoid receptor / 0.757
2aa7 1CAMineralocorticoid receptor / 0.749
2aax PDNMineralocorticoid receptor / 0.738
5hyr ESTEstrogen receptor / 0.725
2b1z 17MEstrogen receptor / 0.713
3uud ESTEstrogen receptor / 0.706
5dxg ESTEstrogen receptor / 0.705
4apu A2KProgesterone receptor / 0.702
5dx3 ESTEstrogen receptor / 0.701
2aa6 STRMineralocorticoid receptor / 0.700
3q95 ESLEstrogen receptor / 0.692
2qgt EEDEstrogen receptor / 0.690
2ao6 R18Androgen receptor / 0.689
1gwr ESTEstrogen receptor / 0.677
3nhx ASDSteroid Delta-isomerase 5.3.3.1 0.675
4pxm ESTEstrogen receptor / 0.675
3uzz ASD3-oxo-5-beta-steroid 4-dehydrogenase / 0.671
2a3i C0RMineralocorticoid receptor / 0.670
2amb 17HAndrogen receptor / 0.666
3d90 NOGProgesterone receptor / 0.664
1p0e PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.663
4e5f 0N7Polymerase acidic protein / 0.662
1ozq PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.661
2z1x PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.661
1efz PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.660
1v2h GUNPurine nucleoside phosphorylase 2.4.2.1 0.660
2puc GUNHTH-type transcriptional repressor PurR / 0.660
4e5l DBHPolymerase acidic protein / 0.660
4ek9 EP4Histone-lysine N-methyltransferase, H3 lysine-79 specific 2.1.1.43 0.660
4hqv QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.659
4hvx QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.659
3bld PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.658
4gcx PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.658
3uzx AOM3-oxo-5-beta-steroid 4-dehydrogenase / 0.657
4hlw TESAndrogen receptor / 0.655
2cbo TH2Neocarzinostatin / 0.654
2pot GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.653
1y9r 1CAMineralocorticoid receptor / 0.652
1h60 STRPentaerythritol tetranitrate reductase / 0.651