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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2w3m FOL Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2w3m FOLDihydrofolate reductase 1.5.1.3 1.051
4keb FOLDihydrofolate reductase 1.5.1.3 0.984
4m6k FOLDihydrofolate reductase 1.5.1.3 0.955
4kfj FOLDihydrofolate reductase 1.5.1.3 0.954
1dhf FOLDihydrofolate reductase 1.5.1.3 0.873
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.850
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.844
4x5g FOLDihydrofolate reductase 1.5.1.3 0.830
1hfq MOTDihydrofolate reductase 1.5.1.3 0.817
1drf FOLDihydrofolate reductase 1.5.1.3 0.805
3ghw GHWDihydrofolate reductase 1.5.1.3 0.804
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.799
3ghv GHCDihydrofolate reductase 1.5.1.3 0.799
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.797
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.790
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.787
3eig MTXDihydrofolate reductase 1.5.1.3 0.785
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.785
7dfr FOLDihydrofolate reductase 1.5.1.3 0.784
4m6l 21VDihydrofolate reductase 1.5.1.3 0.783
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.778
1hfp MOTDihydrofolate reductase 1.5.1.3 0.775
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.775
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.774
4kjj FOLDihydrofolate reductase 1.5.1.3 0.772
1dyh DZFDihydrofolate reductase 1.5.1.3 0.764
4i1n FOLDihydrofolate reductase 1.5.1.3 0.760
4x5f FOLDihydrofolate reductase 1.5.1.3 0.759
3tq9 MTXDihydrofolate reductase / 0.758
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.751
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.749
4qi9 MTXDihydrofolate reductase / 0.749
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.747
3tqb FOLDihydrofolate reductase / 0.747
1dhi MTXDihydrofolate reductase 1.5.1.3 0.744
1dra MTXDihydrofolate reductase 1.5.1.3 0.744
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.744
1dyi FOLDihydrofolate reductase 1.5.1.3 0.743
2d0k FOLDihydrofolate reductase 1.5.1.3 0.743
1hfr MOTDihydrofolate reductase 1.5.1.3 0.739
1u70 MTXDihydrofolate reductase 1.5.1.3 0.737
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.735
2zza FOLDihydrofolate reductase / 0.734
5hi6 MTXDihydrofolate reductase / 0.734
1re7 FOLDihydrofolate reductase 1.5.1.3 0.733
3drc MTXDihydrofolate reductase 1.5.1.3 0.731
3dau MTXDihydrofolate reductase 1.5.1.3 0.730
1drb MTXDihydrofolate reductase 1.5.1.3 0.727
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.727
3och 2MXDihydrofolate reductase 1.5.1.3 0.725
4i13 FOLDihydrofolate reductase 1.5.1.3 0.722
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.722
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.721
1dhj MTXDihydrofolate reductase 1.5.1.3 0.720
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.719
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.718
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.716
3dfr MTXDihydrofolate reductase 1.5.1.3 0.716
1u72 MTXDihydrofolate reductase 1.5.1.3 0.714
2drc MTXDihydrofolate reductase 1.5.1.3 0.714
4dfr MTXDihydrofolate reductase 1.5.1.3 0.714
1df7 MTXDihydrofolate reductase 1.5.1.3 0.713
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.712
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.712
1dre MTXDihydrofolate reductase 1.5.1.3 0.708
1ohk COPDihydrofolate reductase 1.5.1.3 0.708
4p66 MTXDihydrofolate reductase / 0.707
1ohj COPDihydrofolate reductase 1.5.1.3 0.706
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.706
1e26 GPBDihydrofolate reductase 1.5.1.3 0.704
1dls MTXDihydrofolate reductase 1.5.1.3 0.696
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.696
4p68 MTXDihydrofolate reductase / 0.695
1dyj DDFDihydrofolate reductase 1.5.1.3 0.688
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.688
3nxo D2BDihydrofolate reductase 1.5.1.3 0.686
4fhb FOLDihydrofolate reductase 1.5.1.3 0.683
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.682
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.681
1rb2 FOLDihydrofolate reductase 1.5.1.3 0.679
4x5i FOLDihydrofolate reductase 1.5.1.3 0.677
2fzh DH1Dihydrofolate reductase 1.5.1.3 0.675
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.673
3frd DHFDihydrofolate reductase 1.5.1.3 0.667
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.663
2qk8 MTXDihydrofolate reductase / 0.662
1jom FFODihydrofolate reductase 1.5.1.3 0.659
4x5h FOLDihydrofolate reductase 1.5.1.3 0.658
1tdr MTXDihydrofolate reductase 1.5.1.3 0.657
2dhf DZFDihydrofolate reductase 1.5.1.3 0.657
2fzi DH3Dihydrofolate reductase 1.5.1.3 0.652
1jol FFODihydrofolate reductase 1.5.1.3 0.650