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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2vwu 7X1 Ephrin type-B receptor 4 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2vwu 7X1Ephrin type-B receptor 4 2.7.10.1 1.053
2vww 7X2Ephrin type-B receptor 4 2.7.10.1 0.788
3ue4 DB8Tyrosine-protein kinase ABL1 2.7.10.2 0.783
5amn DTQProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.775
2ivu ZD6Proto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.771
4i23 1C9Epidermal growth factor receptor 2.7.10.1 0.755
2vwz 7X6Ephrin type-B receptor 4 2.7.10.1 0.754
4g2f C07Ephrin type-A receptor 3 2.7.10.1 0.751
2vwy 7X5Ephrin type-B receptor 4 2.7.10.1 0.745
4mxy DB8Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.722
4mxz DB8Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.722
2vx0 7X7Ephrin type-B receptor 4 2.7.10.1 0.716
2xvd AS6Ephrin type-B receptor 4 2.7.10.1 0.669
3vw8 DF6Hepatocyte growth factor receptor 2.7.10.1 0.668
4kiq 1RAMitogen-activated protein kinase 14 / 0.666
4qmn DB8Serine/threonine-protein kinase 24 2.7.11.1 0.665
2gtn LIEMitogen-activated protein kinase 14 / 0.659
4gk2 L66Ephrin type-A receptor 3 2.7.10.1 0.657
4jr3 KJREpidermal growth factor receptor 2.7.10.1 0.655
4bc6 XZNSerine/threonine-protein kinase 10 2.7.11.1 0.654
4wkq IREEpidermal growth factor receptor 2.7.10.1 0.654
2xyu Q9GEphrin type-A receptor 4 2.7.10.1 0.653
4afh L0BAchbp / 0.652