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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2vuw 5ID Serine/threonine-protein kinase haspin 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2vuw 5IDSerine/threonine-protein kinase haspin 2.7.11.1 0.950
4ysj ADPCalmodulin-like domain protein kinase / 0.725
3i12 ADPD-alanine--D-alanine ligase A 6.3.2.4 0.714
3bu5 ATPInsulin receptor 2.7.10.1 0.712
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.711
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.708
3t99 ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.707
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.701
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.699
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.698
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.697
2zoq 5IDMitogen-activated protein kinase 3 2.7.11.24 0.697
3nyn SGVG protein-coupled receptor kinase 6 2.7.11.16 0.696
1tqp ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.694
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.694
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.692
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.692
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.692
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.692
3agl A03cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.691
3gub GUBDeath-associated protein kinase 1 2.7.11.1 0.691
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.691
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.691
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.690
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.690
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.689
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.686
2qoq ANPEphrin type-A receptor 3 2.7.10.1 0.685
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.683
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.683
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.681
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.680
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.680
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.679
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.678
2hgs ADPGlutathione synthetase 6.3.2.3 0.677
4q5h ANPProtein kinase OspG 2.7 0.677
3bwj ARXcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.676
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.676
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.676
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.675
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.675
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.675
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.675
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.674
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.673
2olc ADPMethylthioribose kinase 2.7.1.100 0.673
5dt3 ATPAurora kinase A 2.7.11.1 0.673
2pul ACPMethylthioribose kinase 2.7.1.100 0.672
2pui ADPMethylthioribose kinase 2.7.1.100 0.671
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.671
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.671
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.670
4oh4 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.670
2qoc ANPEphrin type-A receptor 3 2.7.10.1 0.669
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.669
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.669
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.669
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.668
3att ATPPutative aminoglycoside phosphotransferase 2.7.1 0.667
3t54 ATPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.666
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.665
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.665
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.664
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.664
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.664
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.663
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.662
2wtk ANPSTE20-related kinase adapter protein alpha / 0.662
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.662
1cm8 ANPMitogen-activated protein kinase 12 / 0.661
4fu0 ADPD-alanine--D-alanine ligase / 0.661
4rr7 A3SProbable threonine--tRNA ligase 2 6.1.1.3 0.661
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.660
3wo1 ADPAlanine--anticapsin ligase / 0.660
3wow ANPCasein kinase II subunit alpha 2.7.11.1 0.660
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.660
4e5f 0N7Polymerase acidic protein / 0.660
2qo9 ANPEphrin type-A receptor 3 2.7.10.1 0.658
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.658
5dn3 ATPAurora kinase A 2.7.11.1 0.658
4oac ADPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.657
4qny ANPMitogen activated protein kinase, putative / 0.656
2vo7 M05cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.655
4dee ADPAurora kinase A 2.7.11.1 0.655
3ibq ATPPyridoxal kinase / 0.654
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.654
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.653
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.653
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.653
2xan ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.653
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.652
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.652
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.651
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.650