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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2vth LZ2 Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2vth LZ2Cyclin-dependent kinase 2 2.7.11.22 0.879
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
3qzg X67Cyclin-dependent kinase 2 2.7.11.22 0.728
4e5l DBHPolymerase acidic protein / 0.713
3ezv EZVCyclin-dependent kinase 2 2.7.11.22 0.701
4fkg 4CKCyclin-dependent kinase 2 2.7.11.22 0.700
4fkj 11KCyclin-dependent kinase 2 2.7.11.22 0.692
3fz1 B98Cyclin-dependent kinase 2 2.7.11.22 0.691
2r3g SC9Cyclin-dependent kinase 2 2.7.11.22 0.690
1pmv 537Mitogen-activated protein kinase 10 2.7.11.24 0.674
2vti LZ3Cyclin-dependent kinase 2 2.7.11.22 0.671
4fkv 61KCyclin-dependent kinase 2 2.7.11.22 0.669
1p2a 5BNCyclin-dependent kinase 2 2.7.11.22 0.666
2fzk CTPAspartate carbamoyltransferase regulatory chain / 0.666
3ql8 X01Cyclin-dependent kinase 2 2.7.11.22 0.666
2uzu L20cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.664
1gih 1PUCyclin-dependent kinase 2 2.7.11.22 0.663
3oog YTPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.661
4qna X11Serine/threonine-protein kinase 24 2.7.11.1 0.661
1m2p HNACasein kinase II subunit alpha 2.7.11.1 0.660
3gb2 G3BGlycogen synthase kinase-3 beta 2.7.11.26 0.658
2gnh H52cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
3v8s 0HDRho-associated protein kinase 1 2.7.11.1 0.651
3kkv B99cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.650