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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2vhv NAI Alanine dehydrogenase 1.4.1.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2vhv NAIAlanine dehydrogenase 1.4.1.1 1.257
2vhz NAIAlanine dehydrogenase 1.4.1.1 1.046
2vhx NADAlanine dehydrogenase 1.4.1.1 1.027
2voj NADAlanine dehydrogenase 1.4.1.1 1.025
2vhw NAIAlanine dehydrogenase 1.4.1.1 0.942
1pjc NADAlanine dehydrogenase / 0.809
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.808
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.807
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 0.807
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.800
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.793
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.792
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 0.790
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 0.787
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.775
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 0.770
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.765
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.764
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.761
1x7d NADPutative ornithine cyclodeaminase / 0.755
4nd2 A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.753
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 0.751
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.749
2g76 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.749
3wle NAD(R)-specific carbonyl reductase / 0.745
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 0.740
1u7h NADPutative ornithine cyclodeaminase / 0.740
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.740
3adp NAILambda-crystallin 1.1.1.45 0.738
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.737
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.736
4oaq NDPR-specific carbonyl reductase / 0.733
2dph NADFormaldehyde dismutase / 0.730
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.727
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.726
2ekl NADD-3-phosphoglycerate dehydrogenase / 0.724
1pzh NADLactate dehydrogenase / 0.722
4j4b NAIUncharacterized protein / 0.722
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.721
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 0.720
1c1d NAIPhenylalanine dehydrogenase / 0.720
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 0.720
3n7u NADFormate dehydrogenase, chloroplastic/mitochondrial / 0.719
1pl8 NADSorbitol dehydrogenase 1.1.1.14 0.718
4c4o NADSADH / 0.718
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.717
2p9g NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.717
3two NDPMannitol dehydrogenase / 0.717
1adc PADAlcohol dehydrogenase E chain 1.1.1.1 0.716
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 0.716
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.716
1ib6 NADMalate dehydrogenase / 0.714
1uxk NADMalate dehydrogenase / 0.714
3wsw NADL-lactate dehydrogenase / 0.714
2x0i NAIMalate dehydrogenase / 0.712
3q2k NAIProbable oxidoreductase / 0.712
2hu2 NADC-terminal binding protein 1 / 0.711
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.711
2o4c NADErythronate-4-phosphate dehydrogenase / 0.709
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.707
4k28 NADShikimate dehydrogenase family protein / 0.707
1e3l NADAlcohol dehydrogenase 4 1.1.1.1 0.703
1o6z NADMalate dehydrogenase / 0.703
2jhf NADAlcohol dehydrogenase E chain 1.1.1.1 0.703
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.700
3wv7 ADPHmd co-occurring protein HcgE / 0.699
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 0.697
4b7x NAPProbable oxidoreductase / 0.697
1adb CNDAlcohol dehydrogenase E chain 1.1.1.1 0.695
1up7 NAD6-phospho-beta-glucosidase BglT 3.2.1.86 0.695
1yba NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.695
3jv7 NADSecondary alcohol dehydrogenase / 0.695
3oet NADErythronate-4-phosphate dehydrogenase / 0.695
3wv8 ATPHmd co-occurring protein HcgE / 0.695
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.693
2g5c NADPrephenate dehydrogenase / 0.692
1yqd NAPSinapyl alcohol dehydrogenase / 0.691
1lso NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.690
2pa3 NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.690
3nt2 NADInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.690
3ec7 NADInositol 2-dehydrogenase / 0.689
4nu6 NADPhosphonate dehydrogenase 1.20.1.1 0.689
3pef NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.688
2v7g NADUrocanate hydratase 4.2.1.49 0.687
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 0.687
3jyp NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.686
1guy NADMalate dehydrogenase / 0.685
3ikt NADRedox-sensing transcriptional repressor Rex / 0.685
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.682
1t2c NAIL-lactate dehydrogenase 1.1.1.27 0.682
2q3e NAIUDP-glucose 6-dehydrogenase 1.1.1.22 0.682
3qvt NAIMyo-inositol-1-phosphate synthase (Ino1) / 0.682
3tri NAPPyrroline-5-carboxylate reductase / 0.682
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.681
5a04 NDPGlucose-fructose oxidoreductase / 0.681
5ein NAP[LysW]-L-2-aminoadipate 6-phosphate reductase / 0.681
5lc1 NADL-threonine 3-dehydrogenase / 0.681
1u8x NADMaltose-6'-phosphate glucosidase 3.2.1.122 0.680
2ph5 NADHomospermidine synthase / 0.680
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 0.679
1n2s NAIdTDP-4-dehydrorhamnose reductase 1.1.1.133 0.679
3cin NADMyo-inositol-1-phosphate synthase-related protein / 0.679
3ggo NAIPrephenate dehydrogenase / 0.679
3jyo NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.679
4wlv NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.679
1f17 NAIHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.678
3pvz NADUDP-N-acetylglucosamine 4,6-dehydratase / 0.678
1het NADAlcohol dehydrogenase E chain 1.1.1.1 0.676
1yqx NAPSinapyl alcohol dehydrogenase / 0.676
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 0.675
1vjt NADAlpha-glucosidase, putative / 0.675
3onw GDPGuanine nucleotide-binding protein G(i) subunit alpha-1 / 0.675
1pr9 NAPL-xylulose reductase 1.1.1.10 0.674
2qg4 NADUDP-glucose 6-dehydrogenase 1.1.1.22 0.674
4jk3 NADUncharacterized protein / 0.674
1jki NAIInositol-3-phosphate synthase 5.5.1.4 0.673
2jd1 NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase / 0.673
1pzg A3DLactate dehydrogenase / 0.672
3m6i NADL-arabinitol 4-dehydrogenase 1.1.1.12 0.672
4b8z NAPGDP-L-fucose synthase 1.1.1.271 0.672
5a02 NAPGlucose-fructose oxidoreductase / 0.672
2ixa NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.671
2ldb NADL-lactate dehydrogenase 1.1.1.27 0.671
3zw9 NADPeroxisomal bifunctional enzyme 1.1.1.35 0.671
4e5n NADPhosphonate dehydrogenase 1.20.1.1 0.670
4j49 NAIUncharacterized protein / 0.670
2nad NADFormate dehydrogenase / 0.669
3tqh NDPQuinone oxidoreductase / 0.669
4ebf NADPhosphonate dehydrogenase 1.20.1.1 0.669
1q7g NHOHomoserine dehydrogenase 1.1.1.3 0.668
1sow NADL-lactate dehydrogenase 1.1.1.27 0.668
2a92 NAIL-lactate dehydrogenase / 0.668
2dbq NAPGlyoxylate reductase 1.1.1.26 0.668
2ydx NAPMethionine adenosyltransferase 2 subunit beta / 0.668
3qvs NADMyo-inositol-1-phosphate synthase (Ino1) / 0.668
4tvb NADHomospermidine synthase 2.5.1.44 0.668
4xqc NADHomospermidine synthase 2.5.1.44 0.668
5je2 SAHMethyl transferase / 0.668
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 0.667
1heu NADAlcohol dehydrogenase E chain 1.1.1.1 0.667
1up6 NAD6-phospho-beta-glucosidase BglT 3.2.1.86 0.667
4ros APRMalate dehydrogenase / 0.667
3h2s NDPPutative NADH-flavin reductase / 0.666
1cdo NADAlcohol dehydrogenase 1 1.1.1.1 0.665
3qvw NADMyo-inositol-1-phosphate synthase (Ino1) / 0.665
4xgi NADGlutamate dehydrogenase / 0.665
2gna GDUUDP-N-acetylglucosamine 4,6-dehydratase (inverting) 4.2.1.115 0.664
4om8 NAD3-hydroxybutyryl-coA dehydrogenase / 0.664
4xq9 NADHomospermidine synthase 2.5.1.44 0.664
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 0.664
3ggg NADPrephenate dehydrogenase / 0.663
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.663
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 0.663
4e5k NADPhosphonate dehydrogenase 1.20.1.1 0.663
4xrg NADHomospermidine synthase 2.5.1.44 0.663
4nu5 NADPhosphonate dehydrogenase 1.20.1.1 0.661
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 0.661
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.661
1j5p NADL-aspartate dehydrogenase 1.4.1.21 0.660
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 0.660
1uxj NADMalate dehydrogenase / 0.660
2c29 NAPDihydroflavonol 4-reductase / 0.660
3abi NADUncharacterized protein / 0.660
4plp NADHomospermidine synthase 2.5.1.44 0.660
2vq3 NAPMetalloreductase STEAP3 / 0.659
1ez4 NADL-lactate dehydrogenase 1.1.1.27 0.658
1psd NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.658
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.658
1hdo NAPFlavin reductase (NADPH) / 0.657
3doc NADGlyceraldehyde-3-phosphate dehydrogenase / 0.657
3tnf GNPRas-related protein Rab-8A / 0.657
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.657
4rqu NADAlcohol dehydrogenase class-P / 0.657
4y1b NAPAntE / 0.657
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 0.657
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 0.657
1pj2 NAINAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.656
1yf3 SAHDNA adenine methylase / 0.656
4jlo ADPAdenylate kinase / 0.656
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.656
4njo NADD-3-phosphoglycerate dehydrogenase, putative / 0.656
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 0.656
2gsd NADFormate dehydrogenase / 0.655
2h63 NAPBiliverdin reductase A 1.3.1.24 0.655
3nt4 NAIInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.655
3w8f NAD3-hydroxybutyrate dehydrogenase / 0.655
4j43 NADUncharacterized protein / 0.655
4j49 NADUncharacterized protein / 0.655
5aq1 NDPGlucose-6-phosphate 1-dehydrogenase / 0.655
5bsg NAPPyrroline-5-carboxylate reductase / 0.655
1xse NDPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.654
2ztm NADD(-)-3-hydroxybutyrate dehydrogenase / 0.654
2hk9 NAPShikimate dehydrogenase (NADP(+)) / 0.653
2ixb NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.653
3qvx NADMyo-inositol-1-phosphate synthase (Ino1) / 0.652
4bv9 NDPKetimine reductase mu-crystallin 1.5.1.25 0.652
4jl5 ADPAdenylate kinase / 0.652
4weq NAPNAD-dependent dehydrogenase / 0.652
1m75 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.651
4rls NAIL-lactate dehydrogenase A chain 1.1.1.27 0.651
1cul GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short / 0.650
2fzw NADAlcohol dehydrogenase class-3 1.1.1.1 0.650
2glx NDP1,5-anhydro-D-fructose reductase / 0.650
2p9c NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.650
4mkf AP5Adenylate kinase / 0.650