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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2v7g NAD Urocanate hydratase 4.2.1.49

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2v7g NADUrocanate hydratase 4.2.1.49 1.352
2fkn NADUrocanate hydratase 4.2.1.49 1.105
1g1a NADdTDP-glucose 4,6-dehydratase / 0.748
2yg6 FADPutrescine oxidase / 0.733
2ixa NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.715
2yg3 FADPutrescine oxidase / 0.712
2xvf FADPutative flavin-containing monooxygenase / 0.711
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.704
3cn8 FADPolyamine oxidase FMS1 / 0.695
2vhx NADAlanine dehydrogenase 1.4.1.1 0.694
3ec7 NADInositol 2-dehydrogenase / 0.692
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.692
5l3d FADLysine-specific histone demethylase 1A 1 0.692
4ce0 SAHProbable O-methyltransferase / 0.691
4egb NADdTDP-glucose 4,6-dehydratase / 0.691
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 0.690
1bxk NADdTDP-glucose 4,6-dehydratase 2 / 0.689
3jyp NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.689
2vhv NAIAlanine dehydrogenase 1.4.1.1 0.687
3jyq NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.685
3wv8 ATPHmd co-occurring protein HcgE / 0.685
4krh SAMPhosphoethanolamine N-methyltransferase 2 / 0.684
4jk3 NADUncharacterized protein / 0.683
1xcb NADRedox-sensing transcriptional repressor Rex / 0.682
4plp NADHomospermidine synthase 2.5.1.44 0.682
3nlc FADUncharacterized protein / 0.681
3rfx NADUronate dehydrogenase / 0.681
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.680
4fgz SAHPhosphoethanolamine N-methyltransferase / 0.680
1y8q ATPSUMO-activating enzyme subunit 2 6.3.2 0.679
2bra FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.679
4yac NAIC alpha-dehydrogenase / 0.678
2ji6 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.677
3go4 SAHUncharacterized protein / 0.677
4nzh FADL-ornithine N(5)-monooxygenase / 0.677
3int FDAUDP-galactopyranose mutase 5.4.99.9 0.676
3rha FDAPutrescine oxidase / 0.676
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 0.676
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 0.674
1nbi SAMGlycine N-methyltransferase 2.1.1.20 0.674
1p1h NADInositol-3-phosphate synthase 5.5.1.4 0.674
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 0.674
4j49 NADUncharacterized protein / 0.674
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 0.674
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.673
2hun NAD336aa long hypothetical dTDP-glucose 4,6-dehydratase / 0.672
2qe6 SAMUncharacterized protein / 0.672
3pvz NADUDP-N-acetylglucosamine 4,6-dehydratase / 0.672
4nu6 NADPhosphonate dehydrogenase 1.20.1.1 0.672
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 0.672
3sr4 TT8Histone-lysine N-methyltransferase, H3 lysine-79 specific 2.1.1.43 0.671
4hh4 SAHCcbJ / 0.670
5dul NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase / 0.670
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 0.669
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 0.669
3f8d FADNADH oxidase/thioredoxin reductase / 0.669
4c03 SFGProtein arginine N-methyltransferase 6 / 0.669
2ewm NAD(S)-1-Phenylethanol dehydrogenase 1.1.1.311 0.668
2q7v FADThioredoxin reductase / 0.668
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 0.668
1jnz FADAdenylylsulfate reductase, subunit A (AprA) / 0.667
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.667
4id9 NADPutative UDP-glucose 4-epimerase / 0.667
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 0.667
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 0.667
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.666
4e5k NADPhosphonate dehydrogenase 1.20.1.1 0.666
1nqa NADGlyceraldehyde-3-phosphate dehydrogenase / 0.665
2o06 MTASpermidine synthase 2.5.1.16 0.665
3kve FADL-amino-acid oxidase / 0.664
3uj8 SFGPhosphoethanolamine N-methyltransferase / 0.664
4yv1 S4MSpermidine synthase, putative / 0.664
4j4b NAIUncharacterized protein / 0.663
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.663
1pj3 NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.662
1tdk FADL-amino-acid oxidase 1.4.3.2 0.662
1boo SAHModification methylase PvuII 2.1.1.113 0.661
1reo FADL-amino-acid oxidase 1.4.3.2 0.661
3n7u NADFormate dehydrogenase, chloroplastic/mitochondrial / 0.661
4j49 NAIUncharacterized protein / 0.661
4tm3 FADKtzI / 0.661
5dst SAHProtein arginine N-methyltransferase 8 2.1.1 0.661
1c1d NAIPhenylalanine dehydrogenase / 0.660
4xq9 NADHomospermidine synthase 2.5.1.44 0.660
4xrg NADHomospermidine synthase 2.5.1.44 0.660
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 0.659
1yqz FADCoenzyme A disulfide reductase / 0.659
3e8s SAHUncharacterized protein / 0.658
3ntq NADInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.657
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.657
5g3s FDAFlavin-dependent L-tryptophan oxidase VioA / 0.657
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 0.657
1grg FADGlutathione reductase, mitochondrial 1.8.1.7 0.656
1i3l NADUDP-glucose 4-epimerase / 0.656
2hmv ADPKtr system potassium uptake protein A / 0.656
3o9z NADLipopolysaccaride biosynthesis protein wbpB / 0.656
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 0.656
4yv2 S4MSpermidine synthase, putative / 0.656
3ruh NADUDP-N-acetylglucosamine 4-epimerase / 0.655
4uy6 SAHHistidine N-alpha-methyltransferase / 0.655
1jnr FADAdenylylsulfate reductase, subunit A (AprA) / 0.654
2c31 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.654
3cif NADGlyceraldehyde-3-phosphate dehydrogenase / 0.654
3lcc SAHThiocyanate methyltransferase 1 / 0.654
4kwc SAHMethyltransferase domain family / 0.654
5ccx SAHtRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A 2.1.1.220 0.654
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 0.653
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.653
4l7v SAHProtein-L-isoaspartate O-methyltransferase / 0.653
1gv0 NADMalate dehydrogenase / 0.652
1u8x NADMaltose-6'-phosphate glucosidase 3.2.1.122 0.652
2ji9 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.652
2rgo FADAlpha-Glycerophosphate Oxidase / 0.651
3lov FADProtoporphyrinogen oxidase / 0.651
1b3r NADAdenosylhomocysteinase 3.3.1.1 0.650
4e5n NADPhosphonate dehydrogenase 1.20.1.1 0.650
4lwp SAHArginine N-methyltransferase, putative / 0.650