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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2uzw SS4 cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2uzw SS4cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.098
2uzt SS3cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.874
2jdv L20cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.801
3kkv B99cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.793
2jds L20cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.792
2oh0 2PYcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.792
5dgz L20Serine/threonine-protein kinase pim-1 2.7.11.1 0.774
2ojf 4PYcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.769
2uzv SS5cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.768
2uzu L20cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.760
3l9m L9McAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.736
2f7e 2EAcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.730
3l9n L9NcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.711
3v8s 0HDRho-associated protein kinase 1 2.7.11.1 0.710
2f7z 6EAcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.689
2hy0 306Serine/threonine-protein kinase Chk1 2.7.11.1 0.681
1pmv 537Mitogen-activated protein kinase 10 2.7.11.24 0.678
2f2u M77Rho-associated protein kinase 2 2.7.11.1 0.674
2hxq 373Serine/threonine-protein kinase Chk1 2.7.11.1 0.671
2f7x 4EAcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.670
1rek B8LcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.668
1p2a 5BNCyclin-dependent kinase 2 2.7.11.22 0.667
1q8u H52cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.666
1ydr IQPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.661
3oog YTPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.660
3tku M77Serine/threonine-protein kinase MRCK beta 2.7.11.1 0.660
2hxl 422Serine/threonine-protein kinase Chk1 2.7.11.1 0.659
1v0o INRCell division control protein 2 homolog 2.7.11.22 0.656
2jdt I5ScAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.655
2c3i IYZSerine/threonine-protein kinase pim-1 2.7.11.1 0.653
3r8p Z46Cyclin-dependent kinase 2 2.7.11.22 0.652
3ti1 B49Cyclin-dependent kinase 2 2.7.11.22 0.650
3zze 6XPHepatocyte growth factor receptor 2.7.10.1 0.650