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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2uz1 TPP Benzaldehyde lyase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2uz1 TPPBenzaldehyde lyase / 1.241
3iae D7KBenzaldehyde lyase / 1.140
3d7k D7KBenzaldehyde lyase / 1.105
2ag0 TPPBenzaldehyde lyase / 1.036
2ag1 TPPBenzaldehyde lyase / 1.032
4qpz TPPBenzaldehyde lyase / 0.875
3iaf TPPBenzaldehyde lyase / 0.867
5ahk TPPAcetolactate synthase II, large subunit / 0.839
1umc TDP2-oxoisovalerate dehydrogenase subunit alpha 1.2.4.4 0.814
1umc TDP2-oxoisovalerate dehydrogenase subunit beta 1.2.4.4 0.814
5eso TDP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.796
3ey9 TDPPyruvate dehydrogenase [ubiquinone] 1.2.5.1 0.786
2q5o TPWIndole-3-pyruvate decarboxylase 4.1.1.74 0.781
1y9d TPPPyruvate oxidase 1.2.3.3 0.780
1jsc TPPAcetolactate synthase catalytic subunit, mitochondrial 2.2.1.6 0.767
3exh TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1.2.4.1 0.755
3exh TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial 1.2.4.1 0.755
3eya TDPPyruvate dehydrogenase [ubiquinone] 1.2.5.1 0.746
3oe1 TDLPyruvate decarboxylase 4.1.1.1 0.745
4jub TPPBenzoylformate decarboxylase 4.1.1.7 0.742
5dgt TZDBenzoylformate decarboxylase 4.1.1.7 0.742
2vk8 TPPPyruvate decarboxylase isozyme 1 / 0.741
4ju9 TZDBenzoylformate decarboxylase 4.1.1.7 0.741
4ju8 TZDBenzoylformate decarboxylase 4.1.1.7 0.739
1ni4 TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1.2.4.1 0.737
1ni4 TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial 1.2.4.1 0.737
1upa TPPN(2)-(2-carboxyethyl)arginine synthase / 0.736
2ihv TPPN(2)-(2-carboxyethyl)arginine synthase / 0.736
2o1x TDP1-deoxy-D-xylulose-5-phosphate synthase 2.2.1.7 0.734
2q5q TPWIndole-3-pyruvate decarboxylase 4.1.1.74 0.731
4juc TPPBenzoylformate decarboxylase 4.1.1.7 0.729
5c4i TPPOxalate oxidoreductase subunit alpha / 0.729
5c4i TPPOxalate oxidoreductase subunit beta / 0.729
2ez9 TDKPyruvate oxidase 1.2.3.3 0.728
3dv0 TPWPyruvate dehydrogenase E1 component subunit alpha 1.2.4.1 0.728
3dv0 TPWPyruvate dehydrogenase E1 component subunit beta 1.2.4.1 0.728
1ovm TPPIndole-3-pyruvate decarboxylase 4.1.1.74 0.723
5ej6 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.722
5exd TPPOxalate oxidoreductase subunit alpha / 0.721
5exd TPPOxalate oxidoreductase subunit beta / 0.721
2w93 TPPPyruvate decarboxylase isozyme 1 / 0.718
4mpr TPPBenzoylformate decarboxylase 4.1.1.7 0.718
4mq5 TPPBenzoylformate decarboxylase 4.1.1.7 0.714
2ihu TP9N(2)-(2-carboxyethyl)arginine synthase / 0.713
4mzx TZDBenzoylformate decarboxylase 4.1.1.7 0.713
5ej9 TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.713
2jlc TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.712
4gg1 TZDBenzoylformate decarboxylase 4.1.1.7 0.710
3exf TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1.2.4.1 0.709
3exf TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial 1.2.4.1 0.709
2fwn TDPBenzoylformate decarboxylase 4.1.1.7 0.708
3fzn D7KBenzoylformate decarboxylase 4.1.1.7 0.708
4jd5 TZDBenzoylformate decarboxylase 4.1.1.7 0.708
1upb TPPN(2)-(2-carboxyethyl)arginine synthase / 0.707
2vk4 TPPPyruvate decarboxylase 4.1.1.1 0.707
3fsj D7KBenzoylformate decarboxylase 4.1.1.7 0.707
1pvd TPPPyruvate decarboxylase isozyme 1 / 0.706
1w88 TDPPyruvate dehydrogenase E1 component subunit alpha 1.2.4.1 0.706
1w88 TDPPyruvate dehydrogenase E1 component subunit beta 1.2.4.1 0.706
4gm1 TZDBenzoylformate decarboxylase 4.1.1.7 0.706
1pyd TDPPyruvate decarboxylase isozyme 1 / 0.703
4juf TPPBenzoylformate decarboxylase 4.1.1.7 0.703
1pox TPPPyruvate oxidase 1.2.3.3 0.701
1l8a TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.700
4k9p TPPBenzoylformate decarboxylase 4.1.1.7 0.700
2x7j TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.699
2ezt TDMPyruvate oxidase 1.2.3.3 0.698
2iht TPPN(2)-(2-carboxyethyl)arginine synthase / 0.698
4qel TZDBenzoylformate decarboxylase 4.1.1.7 0.698
3dva TPWPyruvate dehydrogenase E1 component subunit alpha 1.2.4.1 0.697
3dva TPWPyruvate dehydrogenase E1 component subunit beta 1.2.4.1 0.697
3zhq TPPMultifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.696
3zhs TD6Multifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.696
3zht TD9Multifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.695
4zp1 TPPPyruvate decarboxylase 4.1.1.1 0.695
2g28 TDKPyruvate dehydrogenase E1 component 1.2.4.1 0.694
3zhr TPPMultifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.693
4gm4 TZDBenzoylformate decarboxylase 4.1.1.7 0.693
1po7 TZDBenzoylformate decarboxylase 4.1.1.7 0.692
2v3w TPPBenzoylformate decarboxylase 4.1.1.7 0.692
5ej4 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.689
1pow TPPPyruvate oxidase 1.2.3.3 0.688
4cok TPPPyruvate decarboxylase / 0.685
4k9n TZDBenzoylformate decarboxylase 4.1.1.7 0.685
1mcz TDPBenzoylformate decarboxylase 4.1.1.7 0.681
2c31 TZDOxalyl-CoA decarboxylase 4.1.1.8 0.681
2r8o T5XTransketolase 1 / 0.681
4k9o TPPBenzoylformate decarboxylase 4.1.1.7 0.681
5ej8 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.681
5esd TDP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.681
3duf R1TPyruvate dehydrogenase E1 component subunit alpha 1.2.4.1 0.678
3duf R1TPyruvate dehydrogenase E1 component subunit beta 1.2.4.1 0.678
1bfd TPPBenzoylformate decarboxylase 4.1.1.7 0.677
1rp7 TZDPyruvate dehydrogenase E1 component 1.2.4.1 0.675
2iea TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.675
5eja TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.674
1ngs TPPTransketolase 1 2.2.1.1 0.673
1upc TPPN(2)-(2-carboxyethyl)arginine synthase / 0.673
2g25 TDKPyruvate dehydrogenase E1 component 1.2.4.1 0.672
2jla TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.672
1tkc M6TTransketolase 1 2.2.1.1 0.667
3upt TPPTransketolase / 0.666
4gm0 TZDBenzoylformate decarboxylase 4.1.1.7 0.665
2r5n TPPTransketolase 1 / 0.662
2pan TDPGlyoxylate carboligase 4.1.1.47 0.661
1gpu THDTransketolase 1 2.2.1.1 0.660
3lq4 TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.658
5ej7 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.658
2ji7 OXTOxalyl-CoA decarboxylase 4.1.1.8 0.657
3lq2 TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.656
1ozh HE3Acetolactate synthase, catabolic 2.2.1.6 0.653