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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2rlc CHD Choloylglycine hydrolase 3.5.1.24

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2rlc CHDCholoylglycine hydrolase 3.5.1.24 1.135
2bjf DXCCholoylglycine hydrolase 3.5.1.24 0.964
2jn3 JN3Fatty acid-binding protein, liver / 0.720
1o1v TCHGastrotropin / 0.718
3w5t LHPVitamin D3 receptor / 0.711
3w5r LOAVitamin D3 receptor / 0.698
2azy CHDPhospholipase A2, major isoenzyme 3.1.1.4 0.694
4q0a 4OAVitamin D3 receptor A / 0.680
5dxg ESTEstrogen receptor / 0.680
1ahi CHO7-alpha-hydroxysteroid dehydrogenase 1.1.1.159 0.676
3g1r FIT3-oxo-5-beta-steroid 4-dehydrogenase / 0.674
4qe6 JN3Bile acid receptor / 0.674
2ft9 CHDFatty acid-binding protein 2, liver / 0.673
3f3y 4OABile salt sulfotransferase 2.8.2.14 0.672
5hyr ESTEstrogen receptor / 0.672
4oed DHTAndrogen receptor / 0.671
3k9v CPS1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial / 0.669
2qd3 CHDFerrochelatase, mitochondrial 4.99.1.1 0.667
2qgt EEDEstrogen receptor / 0.667
2ylq TESAndrogen receptor / 0.667
3w5p 4OAVitamin D3 receptor / 0.667
1qyx ASDEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.665
2yhd TESAndrogen receptor / 0.665
1g50 ESTEstrogen receptor / 0.663
2ylo TESAndrogen receptor / 0.663
1xu9 CPSCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.662
3eqm ASDAromatase 1.14.14.14 0.662
1y9r 1CAMineralocorticoid receptor / 0.661
1d2s DHTSex hormone-binding globulin / 0.660
1efz PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
1m3q ANGN-glycosylase/DNA lyase 3.2.2 0.660
1v2h GUNPurine nucleoside phosphorylase 2.4.2.1 0.660
2ab2 SNLMineralocorticoid receptor / 0.660
2puc GUNHTH-type transcriptional repressor PurR / 0.660
4e5i 0N9Polymerase acidic protein / 0.660
4e5l DBHPolymerase acidic protein / 0.660
4ek9 EP4Histone-lysine N-methyltransferase, H3 lysine-79 specific 2.1.1.43 0.660
4ofr DHTAndrogen receptor / 0.657
5dx3 ESTEstrogen receptor / 0.657
4klr CHDFerrochelatase, mitochondrial 4.99.1.1 0.656
2abi 1CAMineralocorticoid receptor / 0.654
2yja ESTEstrogen receptor / 0.653
2aa7 1CAMineralocorticoid receptor / 0.652
1gs4 ZK5Androgen receptor / 0.650
2q7j TESAndrogen receptor / 0.650