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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2rg6 287 Mitogen-activated protein kinase 14

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2rg6 287Mitogen-activated protein kinase 14 / 1.234
3mvm 39PMitogen-activated protein kinase 14 / 0.932
4kin 1M8Mitogen-activated protein kinase 14 / 0.870
3s4q NK0Mitogen-activated protein kinase 14 / 0.840
4kiq 1RAMitogen-activated protein kinase 14 / 0.838
2rg5 279Mitogen-activated protein kinase 14 / 0.832
3fkl FKLMitogen-activated protein kinase 14 / 0.813
3gfe P37Mitogen-activated protein kinase 14 / 0.805
4aa5 NQBMitogen-activated protein kinase 14 / 0.796
3bx5 304Mitogen-activated protein kinase 14 / 0.791
4kip 1R9Mitogen-activated protein kinase 14 / 0.788
3e93 19BMitogen-activated protein kinase 14 / 0.766
3l8x N4DMitogen-activated protein kinase 14 / 0.763
4aac AAVMitogen-activated protein kinase 14 / 0.761
3cs9 NILTyrosine-protein kinase ABL1 2.7.10.2 0.754
3iph G11Mitogen-activated protein kinase 14 / 0.736
3kq7 KQ7Mitogen-activated protein kinase 14 / 0.736
3bv2 P38Mitogen-activated protein kinase 14 / 0.734
3u8w 09JMitogen-activated protein kinase 14 / 0.727
3fsk RO6Mitogen-activated protein kinase 14 / 0.719
4aa4 QC0Mitogen-activated protein kinase 14 / 0.717
3itz P66Mitogen-activated protein kinase 14 / 0.690
3e92 G6AMitogen-activated protein kinase 14 / 0.679
4uxq 0LIFibroblast growth factor receptor 4 2.7.10.1 0.673
2pl0 STITyrosine-protein kinase Lck 2.7.10.2 0.669
2hzi JINTyrosine-protein kinase ABL1 2.7.10.2 0.665
4aa0 AA0Mitogen-activated protein kinase 14 / 0.662
3ds6 A17Mitogen-activated protein kinase 14 / 0.661
3fsf FSSMitogen-activated protein kinase 14 / 0.660
3mvl 38PMitogen-activated protein kinase 14 / 0.654
3oct 1N1Tyrosine-protein kinase BTK 2.7.10.2 0.653
4tyj 0LIFibroblast growth factor receptor 4 2.7.10.1 0.650