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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2qoq ANP Ephrin type-A receptor 3 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2qoq ANPEphrin type-A receptor 3 2.7.10.1 0.898
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.847
2qo9 ANPEphrin type-A receptor 3 2.7.10.1 0.798
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.763
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
1mqb ANPEphrin type-A receptor 2 2.7.10.1 0.735
2pup ADPMethylthioribose kinase 2.7.1.100 0.731
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.719
3b2t M33Fibroblast growth factor receptor 2 / 0.704
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.701
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.700
3c4z ADPRhodopsin kinase / 0.697
5dt3 ATPAurora kinase A 2.7.11.1 0.696
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.695
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.694
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.691
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.691
2wqe ADPAurora kinase A 2.7.11.1 0.691
3cok ANPSerine/threonine-protein kinase PLK4 2.7.11.21 0.691
4ceg ADPAurora kinase A 2.7.11.1 0.691
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.691
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.690
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.690
4f0f ACPProbable serine/threonine-protein kinase roco4 2.7.11.1 0.690
5dr2 ATPAurora kinase A 2.7.11.1 0.689
4utd ACPAurora kinase A 2.7.11.1 0.688
5dn3 ATPAurora kinase A 2.7.11.1 0.688
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.687
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.687
4f1m ACPProbable serine/threonine-protein kinase roco4 2.7.11.1 0.687
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.687
2qoc ANPEphrin type-A receptor 3 2.7.10.1 0.686
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.686
2vuw 5IDSerine/threonine-protein kinase haspin 2.7.11.1 0.685
4dee ADPAurora kinase A 2.7.11.1 0.685
1jqh ANPInsulin-like growth factor 1 receptor 2.7.10.1 0.683
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.683
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.683
5drd ATPAurora kinase A 2.7.11.1 0.681
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.680
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.679
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.678
3c50 ADPRhodopsin kinase / 0.676
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.676
5csh ATPCasein kinase II subunit alpha 2.7.11.1 0.676
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.676
2pwl ACPFibroblast growth factor receptor 2 / 0.675
2olc ADPMethylthioribose kinase 2.7.1.100 0.674
1mq4 ADPAurora kinase A 2.7.11.1 0.673
1i44 ACPInsulin receptor 2.7.10.1 0.672
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.672
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.671
2pui ADPMethylthioribose kinase 2.7.1.100 0.671
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.671
4j97 ACPFibroblast growth factor receptor 2 / 0.671
2eva ADNMitogen-activated protein kinase kinase kinase 7 2.7.11.25 0.670
5dos ATPAurora kinase A 2.7.11.1 0.670
5l8j ADPAurora kinase A 2.7.11.1 0.670
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.669
1mp8 ADPFocal adhesion kinase 1 2.7.10.2 0.668
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.667
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.667
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.666
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.665
3blq ATPCyclin-dependent kinase 9 2.7.11.22 0.665
1ol6 ATPAurora kinase A 2.7.11.1 0.664
2itv ANPEpidermal growth factor receptor 2.7.10.1 0.664
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.664
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.663
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.663
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.663
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.662
1fin ATPCyclin-dependent kinase 2 2.7.11.22 0.661
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.661
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.660
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.660
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.660
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.659
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.659
4wh2 ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.659
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.658
3nie ANPMitogen-activated protein kinase / 0.658
4fu0 ADPD-alanine--D-alanine ligase / 0.658
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.658
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.657
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.657
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.657
3ori AGSSerine/threonine protein kinase / 0.657
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.657
4f1o ACPProbable serine/threonine-protein kinase roco4 2.7.11.1 0.657
4fg7 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.657
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.657
5dnr ATPAurora kinase A 2.7.11.1 0.657
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.656
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.656
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.656
4o1p ANPRibonuclease L / 0.656
5ce3 ADPProtein kinase YopO / 0.656
2pvy ACPFibroblast growth factor receptor 2 / 0.655
3d5w ADPSerine/threonine-protein kinase PLK / 0.655
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.655
3qc9 ADPRhodopsin kinase / 0.653
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.652
5l8l ADPAurora kinase A 2.7.11.1 0.652
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.651
3cly ACPFibroblast growth factor receptor 2 / 0.651
3kn5 ANPRibosomal protein S6 kinase alpha-5 2.7.11.1 0.651
3ort AGSSerine/threonine protein kinase / 0.651
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.651
1cm8 ANPMitogen-activated protein kinase 12 / 0.650
1u54 ACPActivated CDC42 kinase 1 / 0.650
2pul ACPMethylthioribose kinase 2.7.1.100 0.650
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.650
3q1k ADPD-alanine--D-alanine ligase A 6.3.2.4 0.650