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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2qkr IXM Cdc2-like CDK2/CDC28 like protein kinase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2qkr IXMCdc2-like CDK2/CDC28 like protein kinase / 0.960
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
3l9l L9LcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.711
2vti LZ3Cyclin-dependent kinase 2 2.7.11.22 0.710
4c59 FEFCyclin-G-associated kinase 2.7.11.1 0.695
4fkp LS5Cyclin-dependent kinase 2 2.7.11.22 0.695
4fx3 60KCyclin-dependent kinase 2 2.7.11.22 0.694
2x2m X2MProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.689
1q41 IXMGlycogen synthase kinase-3 beta 2.7.11.26 0.684
1v0o INRCell division control protein 2 homolog 2.7.11.22 0.684
4fkv 61KCyclin-dependent kinase 2 2.7.11.22 0.684
1ke7 LS3Cyclin-dependent kinase 2 2.7.11.22 0.683
3eb0 DRKUncharacterized protein / 0.683
1ke8 LS4Cyclin-dependent kinase 2 2.7.11.22 0.682
2y7j B49Phosphorylase b kinase gamma catalytic chain, liver/testis isoform 2.7.11.19 0.682
1ke5 LS1Cyclin-dependent kinase 2 2.7.11.22 0.680
2x2k X2KProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.677
4fkr 45KCyclin-dependent kinase 2 2.7.11.22 0.677
4qmt H1NSerine/threonine-protein kinase 24 2.7.11.1 0.677
3qrt X14Cyclin-dependent kinase 2 2.7.11.22 0.675
3mtl FEFCyclin-dependent kinase 16 2.7.11.22 0.673
4fkt 48KCyclin-dependent kinase 2 2.7.11.22 0.673
4ks8 B49Serine/threonine-protein kinase PAK 6 2.7.11.1 0.673
1fvt 106Cyclin-dependent kinase 2 2.7.11.22 0.672
3l9m L9McAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.672
1ke6 LS2Cyclin-dependent kinase 2 2.7.11.22 0.669
1ke9 LS5Cyclin-dependent kinase 2 2.7.11.22 0.669
3r8p Z46Cyclin-dependent kinase 2 2.7.11.22 0.667
1e9h INRCyclin-dependent kinase 2 2.7.11.22 0.664
2hog 710Serine/threonine-protein kinase Chk1 2.7.11.1 0.664
2jam J60Calcium/calmodulin-dependent protein kinase type 1G 2.7.11.17 0.664
2jds L20cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.662
2pe0 39Z3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.662
3py0 SU9Cyclin-dependent kinase 2 2.7.11.22 0.662
1p2a 5BNCyclin-dependent kinase 2 2.7.11.22 0.659
2uzt SS3cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.659
3ezr EZRCyclin-dependent kinase 2 2.7.11.22 0.658
3w2c N15Aurora kinase A 2.7.11.1 0.658
2hxq 373Serine/threonine-protein kinase Chk1 2.7.11.1 0.657
3v8s 0HDRho-associated protein kinase 1 2.7.11.1 0.657
4fks 46KCyclin-dependent kinase 2 2.7.11.22 0.655
2c3k ABOSerine/threonine-protein kinase Chk1 2.7.11.1 0.653
4fsq HK3Serine/threonine-protein kinase Chk1 2.7.11.1 0.653
2xik J60Serine/threonine-protein kinase 25 2.7.11.1 0.651
3vs7 KS1Tyrosine-protein kinase HCK 2.7.10.2 0.651