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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2qk8 MTX Dihydrofolate reductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2qk8 MTXDihydrofolate reductase / 1.094
3ia4 MTXDihydrofolate reductase / 0.907
3dat MTXDihydrofolate reductase / 0.884
3drc MTXDihydrofolate reductase 1.5.1.3 0.869
3dau MTXDihydrofolate reductase 1.5.1.3 0.860
5hi6 MTXDihydrofolate reductase / 0.859
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.857
4qi9 MTXDihydrofolate reductase / 0.845
3och 2MXDihydrofolate reductase 1.5.1.3 0.840
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.833
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.828
1dra MTXDihydrofolate reductase 1.5.1.3 0.818
1dls MTXDihydrofolate reductase 1.5.1.3 0.817
3dfr MTXDihydrofolate reductase 1.5.1.3 0.817
2drc MTXDihydrofolate reductase 1.5.1.3 0.814
1u70 MTXDihydrofolate reductase 1.5.1.3 0.812
1df7 MTXDihydrofolate reductase 1.5.1.3 0.807
3tq9 MTXDihydrofolate reductase / 0.801
1dhj MTXDihydrofolate reductase 1.5.1.3 0.800
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.796
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.793
3frd DHFDihydrofolate reductase 1.5.1.3 0.791
1dre MTXDihydrofolate reductase 1.5.1.3 0.787
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.787
4keb FOLDihydrofolate reductase 1.5.1.3 0.769
1dhi MTXDihydrofolate reductase 1.5.1.3 0.766
2zza FOLDihydrofolate reductase / 0.765
1hfr MOTDihydrofolate reductase 1.5.1.3 0.761
4x5h FOLDihydrofolate reductase 1.5.1.3 0.761
1e26 GPBDihydrofolate reductase 1.5.1.3 0.760
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.760
4p66 MTXDihydrofolate reductase / 0.757
1tdr MTXDihydrofolate reductase 1.5.1.3 0.755
1u72 MTXDihydrofolate reductase 1.5.1.3 0.754
4m6k FOLDihydrofolate reductase 1.5.1.3 0.752
4i13 FOLDihydrofolate reductase 1.5.1.3 0.751
4kfj FOLDihydrofolate reductase 1.5.1.3 0.749
1drb MTXDihydrofolate reductase 1.5.1.3 0.744
1hfq MOTDihydrofolate reductase 1.5.1.3 0.741
4x5i FOLDihydrofolate reductase 1.5.1.3 0.732
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.728
1dyi FOLDihydrofolate reductase 1.5.1.3 0.724
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.722
4i1n FOLDihydrofolate reductase 1.5.1.3 0.722
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.722
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.721
4p68 MTXDihydrofolate reductase / 0.718
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.716
2d0k FOLDihydrofolate reductase 1.5.1.3 0.714
4fhb FOLDihydrofolate reductase 1.5.1.3 0.714
1dyh DZFDihydrofolate reductase 1.5.1.3 0.712
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.712
3ghw GHWDihydrofolate reductase 1.5.1.3 0.712
5ccc DDFDihydrofolate reductase 1.5.1.3 0.711
1jom FFODihydrofolate reductase 1.5.1.3 0.708
3tqb FOLDihydrofolate reductase / 0.708
3eig MTXDihydrofolate reductase 1.5.1.3 0.703
1dhf FOLDihydrofolate reductase 1.5.1.3 0.701
1ohk COPDihydrofolate reductase 1.5.1.3 0.697
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.697
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.696
1dyj DDFDihydrofolate reductase 1.5.1.3 0.695
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.694
1drf FOLDihydrofolate reductase 1.5.1.3 0.692
1ohj COPDihydrofolate reductase 1.5.1.3 0.690
4kjj FOLDihydrofolate reductase 1.5.1.3 0.690
2dhf DZFDihydrofolate reductase 1.5.1.3 0.689
1hfp MOTDihydrofolate reductase 1.5.1.3 0.688
1jol FFODihydrofolate reductase 1.5.1.3 0.679
3m08 RARDihydrofolate reductase 1.5.1.3 0.677
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.674
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.673
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.671
1u5a BIKL-lactate dehydrogenase 1.1.1.27 0.668
4x5f FOLDihydrofolate reductase 1.5.1.3 0.664
2w3m FOLDihydrofolate reductase 1.5.1.3 0.662
4dld TZGGlutamate receptor ionotropic, kainate 1 / 0.659
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.657
7dfr FOLDihydrofolate reductase 1.5.1.3 0.657
1ddr MTXDihydrofolate reductase 1.5.1.3 0.655
4dfr MTXDihydrofolate reductase 1.5.1.3 0.655
2eg8 FOTDihydroorotase 3.5.2.3 0.651
2r59 PH0Leukotriene A-4 hydrolase 3.3.2.6 0.651
1njs KEUTrifunctional purine biosynthetic protein adenosine-3 2.1.2.2 0.650