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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2qfx NDP Isocitrate dehydrogenase [NADP], mitochondrial 1.1.1.42

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2qfx NDPIsocitrate dehydrogenase [NADP], mitochondrial 1.1.1.42 1.122
4l03 NAPIsocitrate dehydrogenase [NADP] cytoplasmic 1.1.1.42 0.843
2cmj NAPIsocitrate dehydrogenase [NADP] cytoplasmic 1.1.1.42 0.839
2cmv NAPIsocitrate dehydrogenase [NADP] cytoplasmic 1.1.1.42 0.823
1t0l NAPIsocitrate dehydrogenase [NADP] cytoplasmic 1.1.1.42 0.807
4l04 NAPIsocitrate dehydrogenase [NADP] cytoplasmic 1.1.1.42 0.779
3inm NDPIsocitrate dehydrogenase [NADP] cytoplasmic 1.1.1.42 0.770
4umx NAPIsocitrate dehydrogenase [NADP] cytoplasmic 1.1.1.42 0.766
4l06 NAPIsocitrate dehydrogenase [NADP] cytoplasmic 1.1.1.42 0.759
4aov NAPIsocitrate dehydrogenase [NADP] / 0.755
4umy NAPIsocitrate dehydrogenase [NADP] cytoplasmic 1.1.1.42 0.739
2qfv NAPIsocitrate dehydrogenase [NADP], mitochondrial 1.1.1.42 0.737
4kzo NAPIsocitrate dehydrogenase [NADP] cytoplasmic 1.1.1.42 0.721
2d1c NAPIsocitrate dehydrogenase [NADP] 1.1.1.42 0.674