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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2q8i RDC [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial 2.7.11.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2q8i RDC[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial 2.7.11.2 0.959
2hkj RDCType 2 DNA topoisomerase 6 subunit B / 0.788
4egk RDCHeat shock protein HSP 90-alpha / 0.782
4mpc PV2[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.759
4mpn PV0[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.747
2xd6 XD6ATP-dependent molecular chaperone HSP82 / 0.746
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
1qy8 RDIEndoplasmin / 0.743
2xx2 13CATP-dependent molecular chaperone HSP82 / 0.733
1u0z RDCEndoplasmin / 0.721
2iwu NP5ATP-dependent molecular chaperone HSP82 / 0.691
2xx4 13IATP-dependent molecular chaperone HSP82 / 0.683
2iws NP4ATP-dependent molecular chaperone HSP82 / 0.678
2iwx M1SATP-dependent molecular chaperone HSP82 / 0.660
4e5f 0N7Polymerase acidic protein / 0.660
2gdo 12CSerine/threonine-protein kinase Chk1 2.7.11.1 0.658
2xht C0YHeat shock protein HSP 90-alpha / 0.650