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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2q1l 882 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1.1.1.34

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2q1l 8823-hydroxy-3-methylglutaryl-coenzyme A reductase 1.1.1.34 1.371
2r4f RIE3-hydroxy-3-methylglutaryl-coenzyme A reductase 1.1.1.34 1.039
2q6c HR13-hydroxy-3-methylglutaryl-coenzyme A reductase 1.1.1.34 0.970
3cd5 7HI3-hydroxy-3-methylglutaryl-coenzyme A reductase 1.1.1.34 0.949
2q6b HR23-hydroxy-3-methylglutaryl-coenzyme A reductase 1.1.1.34 0.921
1dq9 HMG3-hydroxy-3-methylglutaryl-coenzyme A reductase 1.1.1.34 0.733
4tny DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.654