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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2pzn 393 Aldose reductase 1.1.1.21

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2pzn 393Aldose reductase 1.1.1.21 1.039
2ikj 393Aldose reductase 1.1.1.21 0.998
3mc5 393Aldose reductase 1.1.1.21 0.994
3m64 393Aldose reductase 1.1.1.21 0.992
2pdc 393Aldose reductase 1.1.1.21 0.952
2pdj 393Aldose reductase 1.1.1.21 0.949
2pdp 393Aldose reductase 1.1.1.21 0.945
2pdu 393Aldose reductase 1.1.1.21 0.870
3lbo LDTAldose reductase 1.1.1.21 0.841
3ghu LDTAldose reductase 1.1.1.21 0.822
3ghs LDTAldose reductase 1.1.1.21 0.816
3lql LDTAldose reductase 1.1.1.21 0.816
3ld5 LDTAldose reductase 1.1.1.21 0.800
1us0 LDTAldose reductase 1.1.1.21 0.797
2iki 388Aldose reductase 1.1.1.21 0.797
3t42 3T4Aldose reductase 1.1.1.21 0.797
3m4h 388Aldose reductase 1.1.1.21 0.793
3ght LDTAldose reductase 1.1.1.21 0.792
2i17 LDTAldose reductase 1.1.1.21 0.775
3lz5 LDTAldose reductase 1.1.1.21 0.775
3m0i ZSTAldose reductase 1.1.1.21 0.775
2i16 LDTAldose reductase 1.1.1.21 0.774
1frb ZSTAldose reductase-related protein 2 / 0.771
3ghr LDTAldose reductase 1.1.1.21 0.763
2qxw LDTAldose reductase 1.1.1.21 0.762
2hvo ZSTAldose reductase 1.1.1.21 0.761
1t40 ID5Aldose reductase 1.1.1.21 0.760
2pdm ZSTAldose reductase 1.1.1.21 0.745
2pdb ZSTAldose reductase 1.1.1.21 0.737
3g5e Q74Aldose reductase 1.1.1.21 0.732
2pd5 ZSTAldose reductase 1.1.1.21 0.728
4yu1 53NAldose reductase 1.1.1.21 0.728
2pdf ZSTAldose reductase 1.1.1.21 0.726
2pdn 47DAldose reductase 1.1.1.21 0.726
1z3n 3NAAldose reductase 1.1.1.21 0.725
2dux ZSTAldose reductase 1.1.1.21 0.718
2duz ZSTAldose reductase 1.1.1.21 0.714
2hvn ZSTAldose reductase 1.1.1.21 0.714
2fz9 ZSTAldose reductase 1.1.1.21 0.713
2hv5 ZSTAldose reductase 1.1.1.21 0.709
2is7 2CLAldose reductase 1.1.1.21 0.708
3len ZSTAldose reductase 1.1.1.21 0.706
2pdq 47DAldose reductase 1.1.1.21 0.704
2pdg 47DAldose reductase 1.1.1.21 0.702
2dv0 ZSTAldose reductase 1.1.1.21 0.698
2pdh 47DAldose reductase 1.1.1.21 0.694
2pdx ZSTAldose reductase 1.1.1.21 0.694
2inz OHPAldose reductase 1.1.1.21 0.692
2pdi ZSTAldose reductase 1.1.1.21 0.689
4gca 2X9Aldose reductase 1.1.1.21 0.687
2nvc ITAAldose reductase 1.1.1.21 0.678
1t41 ID5Aldose reductase 1.1.1.21 0.677
1z89 62PAldose reductase 1.1.1.21 0.676
2fz8 ZSTAldose reductase 1.1.1.21 0.667
3s3g TLTAldose reductase 1.1.1.21 0.666
2ikh LITAldose reductase 1.1.1.21 0.665
1iei ZESAldose reductase 1.1.1.21 0.662