Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2pz5 ACP Fibroblast growth factor receptor 2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2pz5 ACPFibroblast growth factor receptor 2 / 1.027
2pzp ACPFibroblast growth factor receptor 2 / 1.018
2py3 ACPFibroblast growth factor receptor 2 / 1.001
3cly ACPFibroblast growth factor receptor 2 / 0.915
4o4d ATPKinase / 0.825
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.804
2pun ACPMethylthioribose kinase 2.7.1.100 0.791
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.786
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.774
4dee ADPAurora kinase A 2.7.11.1 0.768
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.768
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.764
1u54 ACPActivated CDC42 kinase 1 / 0.759
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.757
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.754
2pyw ADPMethylthioribose kinase 2.7.1.100 0.754
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.752
3orm AGSSerine/threonine protein kinase / 0.747
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.746
5byl GCPBifunctional AAC/APH 2.3.1 0.745
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.744
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.743
3c4z ADPRhodopsin kinase / 0.740
5dr2 ATPAurora kinase A 2.7.11.1 0.738
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.737
2pul ACPMethylthioribose kinase 2.7.1.100 0.735
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.735
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.732
1mq4 ADPAurora kinase A 2.7.11.1 0.732
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.731
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.731
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.730
3eth ATPN5-carboxyaminoimidazole ribonucleotide synthase / 0.730
5eg3 ACPFibroblast growth factor receptor 2 / 0.730
2dwb ANPAurora kinase A 2.7.11.1 0.729
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.729
1m0w ANPGlutathione synthetase 6.3.2.3 0.728
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.727
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.727
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.724
2pup ADPMethylthioribose kinase 2.7.1.100 0.722
3t8o ATPRhodopsin kinase / 0.722
3ori AGSSerine/threonine protein kinase / 0.721
4ceg ADPAurora kinase A 2.7.11.1 0.721
4gyi ADPUncharacterized protein / 0.721
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.720
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.720
5dn3 ATPAurora kinase A 2.7.11.1 0.719
4xlv ACPInsulin receptor 2.7.10.1 0.716
4j98 ACPFibroblast growth factor receptor 2 / 0.712
5dos ATPAurora kinase A 2.7.11.1 0.712
5drd ATPAurora kinase A 2.7.11.1 0.712
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.712
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.711
3qc9 ADPRhodopsin kinase / 0.708
4utd ACPAurora kinase A 2.7.11.1 0.708
4bn1 ADPAurora kinase A 2.7.11.1 0.707
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.707
4jrn ANPRhoptry kinase family protein / 0.707
2xs0 ANPMitogen-activated protein kinase 8 2.7.11.24 0.705
3c4x ATPRhodopsin kinase / 0.705
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.704
3tpt ADPSerine/threonine-protein kinase toxin HipA / 0.703
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.702
3nie ANPMitogen-activated protein kinase / 0.702
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.702
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.702
5l8j ADPAurora kinase A 2.7.11.1 0.702
2pui ADPMethylthioribose kinase 2.7.1.100 0.700
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.700
4y0x ADPSerine/threonine-protein kinase PknG 2.7.11.1 0.700
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.699
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.698
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.696
2olc ADPMethylthioribose kinase 2.7.1.100 0.695
3bu5 ATPInsulin receptor 2.7.10.1 0.695
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.695
4q5j ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.695
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.693
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.692
5dt3 ATPAurora kinase A 2.7.11.1 0.692
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.691
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.691
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.690
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.690
1w2c ANPInositol-trisphosphate 3-kinase A 2.7.1.127 0.689
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.689
5l8l ADPAurora kinase A 2.7.11.1 0.689
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.688
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.687
4o1p ANPRibonuclease L / 0.687
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.686
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.686
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.685
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.684
4n57 ADPAPH(2'')-Id / 0.684
1pk8 ATPSynapsin-1 / 0.683
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.683
1bxr ANPCarbamoyl-phosphate synthase large chain / 0.682
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.682
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.681
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.680
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.679
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.679
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.679
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.679
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.678
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.678
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.678
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.678
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.678
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.678
5iqh GNPBifunctional AAC/APH 2.3.1 0.678
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.677
4pl3 ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.677
5iqb GNPBifunctional AAC/APH 2.3.1 0.677
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.676
3c50 ADPRhodopsin kinase / 0.676
3t9a ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.676
3ung ADPCRISPR system Cmr subunit Cmr2 / 0.676
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.675
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.674
2pml ANPUncharacterized protein / 0.672
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.671
4s33 ANPMitogen-activated protein kinase 1 2.7.11.24 0.671
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.670
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.670
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.670
5l8k ADPAurora kinase A 2.7.11.1 0.670
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.669
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.669
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.669
1ol5 ADPAurora kinase A 2.7.11.1 0.668
1ol6 ATPAurora kinase A 2.7.11.1 0.668
3b2t M33Fibroblast growth factor receptor 2 / 0.668
3c4w ATPRhodopsin kinase / 0.668
3rv4 ADPBiotin carboxylase 6.3.4.14 0.668
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.668
4uux APRCinA-like protein / 0.668
3akl ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.667
4axd ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.667
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.665
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.665
2j0l ANPFocal adhesion kinase 1 2.7.10.2 0.664
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.663
2acx ANPG protein-coupled receptor kinase 6 2.7.11.16 0.663
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.663
4j97 ACPFibroblast growth factor receptor 2 / 0.663
3kn5 ANPRibosomal protein S6 kinase alpha-5 2.7.11.1 0.662
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.662
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.661
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.660
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.660
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.660
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.659
3mfs ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.658
3mfu ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.658
3q5i ANPProtein kinase, putative / 0.658
1day GNPCasein kinase II subunit alpha 2.7.11.1 0.657
3ll9 ADPIsopentenyl phosphate kinase / 0.657
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.657
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.657
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.657
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.655
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.655
1gy3 ATPCyclin-dependent kinase 2 2.7.11.22 0.654
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.654
3att ATPPutative aminoglycoside phosphotransferase 2.7.1 0.654
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.654
3tw6 ADPPyruvate carboxylase / 0.654
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.654
1cm8 ANPMitogen-activated protein kinase 12 / 0.653
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.653
3ruq ADPChaperonin / 0.653
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
2itx ANPEpidermal growth factor receptor 2.7.10.1 0.652
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.652
2j9g ADPBiotin carboxylase 6.3.4.14 0.651
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.651
4ork GDPBifunctional AAC/APH 2.3.1 0.651
3a7j ADPSerine/threonine-protein kinase 24 2.7.11.1 0.650
3g8d ADPBiotin carboxylase 6.3.4.14 0.650
4fg7 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.650