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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2pr2 DG1 Enoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2pr2 DG1Enoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 1.119
2nv6 ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.909
2idz ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.882
2ie0 ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.844
4bii NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.843
4dre NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.830
2aqi NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.820
2ieb ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.804
3of2 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.781
2aq8 NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.778
2ntj P1HEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.778
4trn NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.778
4bqp NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.775
4zju NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.774
4dti NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.771
3oew NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.765
3oey NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.765
5cpb NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.764
1enz NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.758
4oxy NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.758
3uic NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.757
4dqu NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.751
2aqh NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.745
1eny NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.740
2ntv P1HEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.739
2h9i EADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.737
1p44 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.729
2aqk NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.729
2b35 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.724
4m87 NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.721
2ztu NADD(-)-3-hydroxybutyrate dehydrogenase / 0.708
5koi NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.704
1g0n NDPTetrahydroxynaphthalene reductase 1.1.1.252 0.702
4wec NADShort chain dehydrogenase / 0.701
1mg5 NAIAlcohol dehydrogenase 1.1.1.1 0.699
4gh5 NADShort-chain dehydrogenase/reductase SDR / 0.696
2b36 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.695
2yut NAPPutative short-chain oxidoreductase / 0.695
2yw9 NAPEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.693
3w8e NAD3-hydroxybutyrate dehydrogenase / 0.689
4yag NAIC alpha-dehydrogenase / 0.688
1vrw NAIEnoyl-ACP reductase / 0.687
2ztm NADD(-)-3-hydroxybutyrate dehydrogenase / 0.687
4bgi NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.685
4yai NAIC alpha-dehydrogenase / 0.685
2q1s NAIPutative nucleotide sugar epimerase/ dehydratase / 0.683
4lis NADUDP-glucose 4-epimerase (Eurofung) / 0.683
1b16 NAQAlcohol dehydrogenase 1.1.1.1 0.680
1x7g NAPPutative ketoacyl reductase 1.3.1 0.675
4dc0 NDPPutative ketoacyl reductase 1.3.1 0.675
4iqg NAPShort-chain dehydrogenase/reductase SDR / 0.675
1ae1 NAPTropinone reductase 1 / 0.673
5js6 NAD17-beta-hydroxysteroid dehydrogenase 14 1.1.1 0.673
2b37 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.671
4qec NAPElxO / 0.671
1w73 NAP2,4-dienoyl-CoA reductase, mitochondrial 1.3.1.34 0.670
2c59 NADGDP-mannose 3,5-epimerase 5.1.3.18 0.669
2ag5 NAD3-hydroxybutyrate dehydrogenase type 2 / 0.666
2d1y NADOxidoreductase, short-chain dehydrogenase/reductase family / 0.666
3geg NADShort-chain dehydrogenase/reductase SDR / 0.666
3vdq NAD3-hydroxybutyrate dehydrogenase / 0.666
1zid ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.665
3h4v NAPPteridine reductase 1 1.5.1.33 0.665
3o03 NAPDehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) / 0.665
4qxm NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.664
3uce NDPDehydrogenase / 0.663
5jy1 NADPutative short-chain dehydrogenase/reductase / 0.663
2dkn NAI3-alpha-hydroxysteroid dehydrogenase / 0.662
3rue NADUDP-N-acetylglucosamine 4-epimerase / 0.662
4nbt NAD3-oxoacyl-[acyl-carrier-protein] reductase / 0.661
4b79 NADProbable short-chain dehydrogenase / 0.660
2wyv NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.659
2ztl NADD(-)-3-hydroxybutyrate dehydrogenase / 0.659
2b4q NAPRhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase 1.1.1.100 0.658
2wdz NADGalactitol dehydrogenase / 0.658
3zu2 NAIEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.657
1rwb NADGlucose 1-dehydrogenase 1.1.1.47 0.655
2c29 NAPDihydroflavonol 4-reductase / 0.653
3ndr NADPyridoxal 4-dehydrogenase 1.1.1.107 0.653
3orf NADDihydropteridine reductase 1.5.1.34 0.653
3wmx NADNAD dependent epimerase/dehydratase / 0.653
1kvr NADUDP-glucose 4-epimerase 5.1.3.2 0.652
4cql NADEstradiol 17-beta-dehydrogenase 8 1.1.1.62 0.652
1gco NADGlucose 1-dehydrogenase 1.1.1.47 0.651
1gee NADGlucose 1-dehydrogenase 1.1.1.47 0.651
1iy8 NADLevodione reductase / 0.650
2yy7 NADL-threonine dehydrogenase / 0.650
3w8d NAD3-hydroxybutyrate dehydrogenase / 0.650