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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2pks G44 Prothrombin 3.4.21.5

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2pks G44Prothrombin 3.4.21.5 0.879
2zhf 49UProthrombin 3.4.21.5 0.707
2zhq 27UProthrombin 3.4.21.5 0.702
2zi2 24UProthrombin 3.4.21.5 0.701
1vzq SHYProthrombin 3.4.21.5 0.698
4ayy 9MXProthrombin 3.4.21.5 0.694
2c4f GILCoagulation factor VII 3.4.21.21 0.692
1gj4 132Prothrombin 3.4.21.5 0.691
3utu 1TSProthrombin 3.4.21.5 0.689
1c5n ESIProthrombin 3.4.21.5 0.679
1d4p BPPProthrombin 3.4.21.5 0.679
1ypk CCRProthrombin 3.4.21.5 0.675
2zda 32UProthrombin 3.4.21.5 0.673
1lpk CBBCoagulation factor X 3.4.21.6 0.670
2gde SN3Prothrombin 3.4.21.5 0.669
4az2 9MUProthrombin 3.4.21.5 0.669
2zgx 29UProthrombin 3.4.21.5 0.667
3v0x ANHCationic trypsin 3.4.21.4 0.664
1drt PCVClavaminate synthase 1 1.14.11.21 0.660
1n35 CH1RNA-directed RNA polymerase lambda-3 2.7.7.48 0.660
1o0d 163Prothrombin 3.4.21.5 0.660
1wet GUNHTH-type transcriptional repressor PurR / 0.660
2fzk CTPAspartate carbamoyltransferase regulatory chain / 0.660
2jey HLOAcetylcholinesterase 3.1.1.7 0.660
2oap ANPType II secretion system protein (GspE-2) / 0.660
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.660
3cwq ADPParA family chromosome partitioning protein / 0.660
3f8p NADNADH oxidase/thioredoxin reductase / 0.660
3f8r NAPNADH oxidase/thioredoxin reductase / 0.660
3fzf ATPHeat shock cognate 71 kDa protein / 0.660
3u9d ATPActin, alpha skeletal muscle / 0.660
3ypi PGHTriosephosphate isomerase 5.3.1.1 0.660
3zzn ADPL-lactate dehydrogenase / 0.660
4e5l DBHPolymerase acidic protein / 0.660
4ax9 N5NProthrombin 3.4.21.5 0.659
2cf8 ESHProthrombin 3.4.21.5 0.657
4ayv 9MQProthrombin 3.4.21.5 0.657
2hru ADPPhosphoribosylformylglycinamidine synthase subunit PurL / 0.656
1ypl RA8Prothrombin 3.4.21.5 0.654
2zp0 PI0Coagulation factor VII 3.4.21.21 0.653
1ype UIPProthrombin 3.4.21.5 0.652
1ypm RA4Prothrombin 3.4.21.5 0.651