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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2ph8 35A Beta-secretase 1 3.4.23.46

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2ph8 35ABeta-secretase 1 3.4.23.46 1.136
2ph6 712Beta-secretase 1 3.4.23.46 0.941
2irz I02Beta-secretase 1 3.4.23.46 0.830
2ntr L00Beta-secretase 1 3.4.23.46 0.822
2is0 I03Beta-secretase 1 3.4.23.46 0.756
2oah QINBeta-secretase 1 3.4.23.46 0.705
2qzl IXSBeta-secretase 1 3.4.23.46 0.663
2fdp FRPBeta-secretase 1 3.4.23.46 0.653
3ccc 7ACDipeptidyl peptidase 4 / 0.651