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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2ph6 712 Beta-secretase 1 3.4.23.46

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2ph6 712Beta-secretase 1 3.4.23.46 1.364
2irz I02Beta-secretase 1 3.4.23.46 1.224
2is0 I03Beta-secretase 1 3.4.23.46 1.123
2ntr L00Beta-secretase 1 3.4.23.46 1.028
2ph8 35ABeta-secretase 1 3.4.23.46 0.941
2qzl IXSBeta-secretase 1 3.4.23.46 0.859
1tqf 32PBeta-secretase 1 3.4.23.46 0.853
4fco 0U4Beta-secretase 1 3.4.23.46 0.765
2vkm BSDBeta-secretase 1 3.4.23.46 0.735
2oah QINBeta-secretase 1 3.4.23.46 0.718
2viz VG4Beta-secretase 1 3.4.23.46 0.696
3ixk 929Beta-secretase 1 3.4.23.46 0.696
2wf4 ZY4Beta-secretase 1 3.4.23.46 0.688
2wf2 ZY2Beta-secretase 1 3.4.23.46 0.684
2vij C44Beta-secretase 1 3.4.23.46 0.682
2vj6 VG5Beta-secretase 1 3.4.23.46 0.676
4gid 0GHBeta-secretase 1 3.4.23.46 0.670
2wf3 ZY3Beta-secretase 1 3.4.23.46 0.668
2wez ZYEBeta-secretase 1 3.4.23.46 0.664
3k5f AYHBeta-secretase 1 3.4.23.46 0.657
2fdp FRPBeta-secretase 1 3.4.23.46 0.656