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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2pe1 517 3-phosphoinositide-dependent protein kinase 1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2pe1 5173-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.910
2pe2 4643-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.836
2pe0 39Z3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.755
2x2k X2KProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.692
2bfy H1NAurora kinase B-A 2.7.11.1 0.690
1v0o INRCell division control protein 2 homolog 2.7.11.22 0.688
1e9h INRCyclin-dependent kinase 2 2.7.11.22 0.684
3g0f B49Mast/stem cell growth factor receptor Kit 2.7.10.1 0.677
2x2m X2MProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.670
3c7q XINVascular endothelial growth factor receptor 2 2.7.10.1 0.666
2hxl 422Serine/threonine-protein kinase Chk1 2.7.11.1 0.664
2xik J60Serine/threonine-protein kinase 25 2.7.11.1 0.661
1ydr IQPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.659
2c1a I5ScAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.659
3qcq 3Q03-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.658
3qcy 3Q33-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.657
2y7j B49Phosphorylase b kinase gamma catalytic chain, liver/testis isoform 2.7.11.19 0.656
4fks 46KCyclin-dependent kinase 2 2.7.11.22 0.656
4fx3 60KCyclin-dependent kinase 2 2.7.11.22 0.653
2hog 710Serine/threonine-protein kinase Chk1 2.7.11.1 0.651
2hxq 373Serine/threonine-protein kinase Chk1 2.7.11.1 0.651
3qcs 3Q13-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.651