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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2pe0 39Z 3-phosphoinositide-dependent protein kinase 1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2pe0 39Z3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.902
2pe1 5173-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.755
4e5i 0N9Polymerase acidic protein / 0.744
2pe2 4643-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.715
3c7q XINVascular endothelial growth factor receptor 2 2.7.10.1 0.690
4fkq 42KCyclin-dependent kinase 2 2.7.11.22 0.686
2x2m X2MProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.681
2xik J60Serine/threonine-protein kinase 25 2.7.11.1 0.681
2gnl H52cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.679
1v0o INRCell division control protein 2 homolog 2.7.11.22 0.678
2x2k X2KProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.675
1e9h INRCyclin-dependent kinase 2 2.7.11.22 0.672
1q8u H52cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.672
4fsn A58Serine/threonine-protein kinase Chk1 2.7.11.1 0.672
2hog 710Serine/threonine-protein kinase Chk1 2.7.11.1 0.671
2hy0 306Serine/threonine-protein kinase Chk1 2.7.11.1 0.671
4qmt H1NSerine/threonine-protein kinase 24 2.7.11.1 0.671
4fks 46KCyclin-dependent kinase 2 2.7.11.22 0.666
1q41 IXMGlycogen synthase kinase-3 beta 2.7.11.26 0.664
4fsq HK3Serine/threonine-protein kinase Chk1 2.7.11.1 0.663
2qkr IXMCdc2-like CDK2/CDC28 like protein kinase / 0.662
2x2l X2LProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.660
4e5f 0N7Polymerase acidic protein / 0.660
4fx3 60KCyclin-dependent kinase 2 2.7.11.22 0.658
2bfy H1NAurora kinase B-A 2.7.11.1 0.657
4fsr HKCSerine/threonine-protein kinase Chk1 2.7.11.1 0.655
2wkm PFYHepatocyte growth factor receptor 2.7.10.1 0.653
2ym6 YM6Serine/threonine-protein kinase Chk1 2.7.11.1 0.653
4fkw 62KCyclin-dependent kinase 2 2.7.11.22 0.653
2hxq 373Serine/threonine-protein kinase Chk1 2.7.11.1 0.651
4ftl H0KSerine/threonine-protein kinase Chk1 2.7.11.1 0.651
3nun JMZ3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.650
4agd B49Vascular endothelial growth factor receptor 2 2.7.10.1 0.650