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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2pdu 393 Aldose reductase 1.1.1.21

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2pdu 393Aldose reductase 1.1.1.21 0.980
3mc5 393Aldose reductase 1.1.1.21 0.875
2pdp 393Aldose reductase 1.1.1.21 0.873
2pzn 393Aldose reductase 1.1.1.21 0.870
2pdj 393Aldose reductase 1.1.1.21 0.865
3m64 393Aldose reductase 1.1.1.21 0.848
2ikj 393Aldose reductase 1.1.1.21 0.846
2pdc 393Aldose reductase 1.1.1.21 0.838
3m4h 388Aldose reductase 1.1.1.21 0.812
3lbo LDTAldose reductase 1.1.1.21 0.799
3t42 3T4Aldose reductase 1.1.1.21 0.794
3lz5 LDTAldose reductase 1.1.1.21 0.780
2fz9 ZSTAldose reductase 1.1.1.21 0.769
3ld5 LDTAldose reductase 1.1.1.21 0.768
2iki 388Aldose reductase 1.1.1.21 0.763
2qxw LDTAldose reductase 1.1.1.21 0.756
2duz ZSTAldose reductase 1.1.1.21 0.755
3ghu LDTAldose reductase 1.1.1.21 0.752
2pdb ZSTAldose reductase 1.1.1.21 0.751
2fz8 ZSTAldose reductase 1.1.1.21 0.749
2pdq 47DAldose reductase 1.1.1.21 0.747
2pdm ZSTAldose reductase 1.1.1.21 0.744
2hvn ZSTAldose reductase 1.1.1.21 0.741
3ghs LDTAldose reductase 1.1.1.21 0.737
3ghr LDTAldose reductase 1.1.1.21 0.736
3ght LDTAldose reductase 1.1.1.21 0.733
2i17 LDTAldose reductase 1.1.1.21 0.731
1us0 LDTAldose reductase 1.1.1.21 0.729
2i16 LDTAldose reductase 1.1.1.21 0.729
2dv0 ZSTAldose reductase 1.1.1.21 0.728
3g5e Q74Aldose reductase 1.1.1.21 0.728
3lql LDTAldose reductase 1.1.1.21 0.727
1frb ZSTAldose reductase-related protein 2 / 0.726
2pd5 ZSTAldose reductase 1.1.1.21 0.722
2pdi ZSTAldose reductase 1.1.1.21 0.722
2hvo ZSTAldose reductase 1.1.1.21 0.721
2hv5 ZSTAldose reductase 1.1.1.21 0.713
1t40 ID5Aldose reductase 1.1.1.21 0.698
2pdh 47DAldose reductase 1.1.1.21 0.690
2dux ZSTAldose reductase 1.1.1.21 0.689
4gca 2X9Aldose reductase 1.1.1.21 0.686
1iei ZESAldose reductase 1.1.1.21 0.683
1z3n 3NAAldose reductase 1.1.1.21 0.683
3m0i ZSTAldose reductase 1.1.1.21 0.683
2pdn 47DAldose reductase 1.1.1.21 0.680
2pdx ZSTAldose reductase 1.1.1.21 0.678
3len ZSTAldose reductase 1.1.1.21 0.677
2is7 2CLAldose reductase 1.1.1.21 0.676
2ikh LITAldose reductase 1.1.1.21 0.675
2pdg 47DAldose reductase 1.1.1.21 0.672
2inz OHPAldose reductase 1.1.1.21 0.662
4yu1 53NAldose reductase 1.1.1.21 0.658