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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2pb6 SAH Diphthine synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2pb6 SAHDiphthine synthase / 1.139
2e8r SAHDiphthine synthase / 1.131
2pb4 SAHDiphthine synthase / 1.116
2pb5 SAHDiphthine synthase / 1.115
2dv5 SAHDiphthine synthase / 1.114
2p6l SAHDiphthine synthase / 1.114
2p6k SAHDiphthine synthase / 1.113
2eh5 SAHDiphthine synthase / 1.112
2el3 SAHDiphthine synthase / 1.112
2pcg SAHDiphthine synthase / 1.111
2eh4 SAHDiphthine synthase / 1.110
2emr SAHDiphthine synthase / 1.109
2en5 SAHDiphthine synthase / 1.109
2eka SAHDiphthine synthase / 1.108
2p6d SAHDiphthine synthase / 1.099
2emu SAHDiphthine synthase / 1.096
2p9d SAHDiphthine synthase / 1.096
2dsi SAHDiphthine synthase / 1.095
2e8s SAHDiphthine synthase / 1.095
2ek4 SAHDiphthine synthase / 1.095
2ek7 SAHDiphthine synthase / 1.095
2eld SAHDiphthine synthase / 1.094
2pck SAHDiphthine synthase / 1.094
2ed5 SAHDiphthine synthase / 1.093
2eeq SAHDiphthine synthase / 1.093
2dv3 SAHDiphthine synthase / 1.092
2ek3 SAHDiphthine synthase / 1.092
2pca SAHDiphthine synthase / 1.092
2dxx SAHDiphthine synthase / 1.091
2e17 SAHDiphthine synthase / 1.091
2e4n SAHDiphthine synthase / 1.091
2owg SAHDiphthine synthase / 1.089
2p5f SAHDiphthine synthase / 1.082
2ejk SAHDiphthine synthase / 1.081
2eni SAHDiphthine synthase / 1.080
2p5c SAHDiphthine synthase / 1.079
2pcm SAHDiphthine synthase / 1.079
2e16 SAHDiphthine synthase / 1.078
2dv4 SAHDiphthine synthase / 1.077
2e08 SAHDiphthine synthase / 1.077
2ele SAHDiphthine synthase / 1.076
2owk SAHDiphthine synthase / 1.076
2pch SAHDiphthine synthase / 1.075
2ek2 SAHDiphthine synthase / 1.074
2dsg SAHDiphthine synthase / 1.073
2dsh SAHDiphthine synthase / 1.073
2e15 SAHDiphthine synthase / 1.073
2egs SAHDiphthine synthase / 1.073
2dxw SAHDiphthine synthase / 1.072
2el0 SAHDiphthine synthase / 1.072
1wng SAHDiphthine synthase / 1.070
2e8h SAHDiphthine synthase / 1.060
2e8q SAHDiphthine synthase / 1.060
2p6i SAHDiphthine synthase / 1.060
2egl SAHDiphthine synthase / 1.056
1vce SAHDiphthine synthase / 1.055
2e07 SAHDiphthine synthase / 1.055
2e7r SAHDiphthine synthase / 1.055
2egb SAHDiphthine synthase / 1.055
2dv7 SAHDiphthine synthase / 1.054
2dxv SAHDiphthine synthase / 1.054
2ehl SAHDiphthine synthase / 1.054
2huv SAHDiphthine synthase / 1.054
2eh2 SAHDiphthine synthase / 1.042
2ejj SAHDiphthine synthase / 1.041
2dek SAHDiphthine synthase / 1.040
2z6r SAHDiphthine synthase / 1.039
2owu SAHDiphthine synthase / 1.032
2huq SAHDiphthine synthase / 1.024
2pci SAHDiphthine synthase / 1.023
2owv SAHDiphthine synthase / 1.020
2hut SAHDiphthine synthase / 0.995
2p2x SAHDiphthine synthase / 0.992
2hux SAHDiphthine synthase / 0.954
2hr8 SAHDiphthine synthase / 0.881
2ejz SAHDiphthine synthase / 0.799
2owf SAHDiphthine synthase / 0.763
2ed3 SAHDiphthine synthase / 0.723
2egv SAMRibosomal RNA small subunit methyltransferase E 2.1.1.193 0.711
1jgt APCCarboxyethyl-arginine beta-lactam-synthase 6.3.3.4 0.679
1s4d SAHUroporphyrinogen-III C-methyltransferase 2.1.1.107 0.671
1kp2 ATPArgininosuccinate synthase 6.3.4.5 0.669
3nd1 SAHPrecorrin-6A synthase (Deacetylating) / 0.669
4rrm A3TProbable threonine--tRNA ligase 2 6.1.1.3 0.669
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.665
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.662
5a7y SAHtRNA (adenine(9)-N1)-methyltransferase 2.1.1.218 0.661
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.660
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.659
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.659
3nut SAHPrecorrin-3 methylase / 0.658
2ioa ADPBifunctional glutathionylspermidine synthetase/amidase / 0.656
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.656
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.650
3ndc SAHPrecorrin-4 C(11)-methyltransferase 2.1.1.133 0.650
4rrb A3TProbable threonine--tRNA ligase 2 6.1.1.3 0.650