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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2p55 MRA Dual specificity mitogen-activated protein kinase kinase 1 2.7.12.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2p55 MRADual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 1.108
3vvh 4BMDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.906
3dv3 MEKDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.874
4anb YQYDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.857
3os3 3OSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.849
4an2 EUIDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.788
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
1s9j BBMDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.717
4lmn EUIDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.701
3e8n VRADual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.700
3v01 3V0Dual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.673
4e5f 0N7Polymerase acidic protein / 0.660
2ynf WHUGag-Pol polyprotein 2.7.7.49 0.652
3mla JJZProbable nicotinate-nucleotide adenylyltransferase / 0.652
3qqs 17CAnthranilate phosphoribosyltransferase / 0.650