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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2p2m PRX Acetyl-coenzyme A synthetase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2p2m PRXAcetyl-coenzyme A synthetase / 1.057
2p2j PRXAcetyl-coenzyme A synthetase / 0.978
2p20 PRXAcetyl-coenzyme A synthetase / 0.973
2p2b PRXAcetyl-coenzyme A synthetase / 0.963
1pg3 PRXAcetyl-coenzyme A synthetase / 0.955
2p2q PRXAcetyl-coenzyme A synthetase / 0.895
5ifi PRXAcetyl-coenzyme A synthetase / 0.819
4r1l ADPPhenylacetate-coenzyme A ligase / 0.739
1v25 ANPLong-chain-fatty-acid--CoA ligase 6.2.1.3 0.703
4rvo ADPPhenylacetate-coenzyme A ligase / 0.700
3ies M24Luciferin 4-monooxygenase 1.13.12.7 0.698
4oxi GAPEnterobactin synthetase component F-related protein / 0.680
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.677
2yw2 ATPPhosphoribosylamine--glycine ligase / 0.671
2p0a ANPSynapsin-3 / 0.666
4g36 SLULuciferin 4-monooxygenase 1.13.12.7 0.664
3lgx ATPD-alanine--poly(phosphoribitol) ligase subunit 1 / 0.663
4h12 SAHHistone-lysine N-methyltransferase SETD2 2.1.1.43 0.661
2d1s SLULuciferin 4-monooxygenase 1.13.12.7 0.660
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.657
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.655
3rv4 ADPBiotin carboxylase 6.3.4.14 0.655