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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2osc MUH Angiopoietin-1 receptor 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2osc MUHAngiopoietin-1 receptor 2.7.10.1 1.219
5hid B1ESerine/threonine-protein kinase B-raf 2.7.11.1 0.721
4equ G6ISerine/threonine-protein kinase 10 2.7.11.1 0.714
4ckr DI1Epithelial discoidin domain-containing receptor 1 2.7.10.1 0.712
1iep STITyrosine-protein kinase ABL1 2.7.10.2 0.706
2e2b 406Tyrosine-protein kinase ABL1 2.7.10.2 0.703
3ugc 046Tyrosine-protein kinase JAK2 / 0.699
3cs9 NILTyrosine-protein kinase ABL1 2.7.10.2 0.682
4tyj 0LIFibroblast growth factor receptor 4 2.7.10.1 0.680
3kq7 KQ7Mitogen-activated protein kinase 14 / 0.677
2xht C0YHeat shock protein HSP 90-alpha / 0.675
2hiw 7MPTyrosine-protein kinase ABL1 2.7.10.2 0.668
1wbt WBTMitogen-activated protein kinase 14 / 0.662
1ywn LIFVascular endothelial growth factor receptor 2 2.7.10.1 0.660
2p15 EZTEstrogen receptor / 0.660
4uxq 0LIFibroblast growth factor receptor 4 2.7.10.1 0.654